FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1565332914> ?p ?o ?g. }

• W1565332914 endingPage "22913" @default.
• W1565332914 startingPage "22908" @default.
• W1565332914 abstract "Phosphatidylglycerophosphate (PGP) synthase catalyzes a reaction involved in the synthesis of phosphatidylglycerol (PG), which serves as a metabolic precursor for cardiolipin (CL), found primarily in the mitochondrial membranes of eukaryotic cells. We isolated a Chinese hamster ovary cell mutant (designated PGS-S) with a specific lesion in PGP synthase by using an in situ enzymatic assay for the enzyme. This mutant was obtained by introducing a second mutation into mutant PGS-P that had been generated by first-step mutagenesis. The PGP synthase activities in cell extracts of mutant PGS-S grown at 33 and 40 degrees C were 14 and 1% of those in the wild type cells, respectively; in addition, PGP synthase in cell extracts of mutant PGS-S exhibited higher sensitivity to heat than that of the wild type. Mutant PGS-S also showed a temperature-dependent defect in the synthesis of PG and CL in vivo, together with temperature sensitivity for cell growth. A temperature-resistant revertant of mutant PGS-S simultaneously restored PGP synthase activity and the ability to synthesize PG and CL in vivo to nearly the same levels as those of mutant PGS-P. These results constitute genetic evidence that PGP synthase is responsible for PG synthesis and is essential for cell growth." @default.
• W1565332914 created "2016-06-24" @default.
• W1565332914 creator A5048811008 @default.
• W1565332914 creator A5051685552 @default.
• W1565332914 creator A5076364285 @default.
• W1565332914 date "1993-10-01" @default.
• W1565332914 modified "2023-10-15" @default.
• W1565332914 title "A somatic cell mutant defective in phosphatidylglycerophosphate synthase, with impaired phosphatidylglycerol and cardiolipin biosynthesis." @default.
• W1565332914 cites W1499845352 @default.
• W1565332914 cites W1539603883 @default.
• W1565332914 cites W1542916233 @default.
• W1565332914 cites W1546670038 @default.
• W1565332914 cites W1554718847 @default.
• W1565332914 cites W1569409978 @default.
• W1565332914 cites W1570483040 @default.
• W1565332914 cites W1576429697 @default.
• W1565332914 cites W1577386926 @default.
• W1565332914 cites W1587509135 @default.
• W1565332914 cites W1659530831 @default.
• W1565332914 cites W1775749144 @default.
• W1565332914 cites W1778417675 @default.
• W1565332914 cites W1976840952 @default.
• W1565332914 cites W1981261838 @default.
• W1565332914 cites W2009798851 @default.
• W1565332914 cites W2023447188 @default.
• W1565332914 cites W2031169802 @default.
• W1565332914 cites W2035844149 @default.
• W1565332914 cites W2041651125 @default.
• W1565332914 cites W2056795168 @default.
• W1565332914 cites W2061213072 @default.
• W1565332914 cites W2068084192 @default.
• W1565332914 cites W2083504696 @default.
• W1565332914 cites W2122415937 @default.
• W1565332914 cites W2151862216 @default.
• W1565332914 cites W2152214802 @default.
• W1565332914 cites W2300552860 @default.
• W1565332914 cites W2418651706 @default.
• W1565332914 cites W62573283 @default.
• W1565332914 cites W75797419 @default.
• W1565332914 doi "https://doi.org/10.1016/s0021-9258(18)41612-2" @default.
• W1565332914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8226800" @default.
• W1565332914 hasPublicationYear "1993" @default.
• W1565332914 type Work @default.
• W1565332914 sameAs 1565332914 @default.
• W1565332914 citedByCount "59" @default.
• W1565332914 countsByYear W15653329142012 @default.
• W1565332914 countsByYear W15653329142013 @default.
• W1565332914 countsByYear W15653329142014 @default.
• W1565332914 countsByYear W15653329142015 @default.
• W1565332914 countsByYear W15653329142016 @default.
• W1565332914 countsByYear W15653329142019 @default.
• W1565332914 crossrefType "journal-article" @default.
• W1565332914 hasAuthorship W1565332914A5048811008 @default.
• W1565332914 hasAuthorship W1565332914A5051685552 @default.
• W1565332914 hasAuthorship W1565332914A5076364285 @default.
• W1565332914 hasBestOaLocation W15653329141 @default.
• W1565332914 hasConcept C104317684 @default.
• W1565332914 hasConcept C112243037 @default.
• W1565332914 hasConcept C134305767 @default.
• W1565332914 hasConcept C143065580 @default.
• W1565332914 hasConcept C181199279 @default.
• W1565332914 hasConcept C185592680 @default.
• W1565332914 hasConcept C2776330855 @default.
• W1565332914 hasConcept C2778918659 @default.
• W1565332914 hasConcept C2780726299 @default.
• W1565332914 hasConcept C2781302388 @default.
• W1565332914 hasConcept C41625074 @default.
• W1565332914 hasConcept C553450214 @default.
• W1565332914 hasConcept C55493867 @default.
• W1565332914 hasConcept C86803240 @default.
• W1565332914 hasConcept C95444343 @default.
• W1565332914 hasConceptScore W1565332914C104317684 @default.
• W1565332914 hasConceptScore W1565332914C112243037 @default.
• W1565332914 hasConceptScore W1565332914C134305767 @default.
• W1565332914 hasConceptScore W1565332914C143065580 @default.
• W1565332914 hasConceptScore W1565332914C181199279 @default.
• W1565332914 hasConceptScore W1565332914C185592680 @default.
• W1565332914 hasConceptScore W1565332914C2776330855 @default.
• W1565332914 hasConceptScore W1565332914C2778918659 @default.
• W1565332914 hasConceptScore W1565332914C2780726299 @default.
• W1565332914 hasConceptScore W1565332914C2781302388 @default.
• W1565332914 hasConceptScore W1565332914C41625074 @default.
• W1565332914 hasConceptScore W1565332914C553450214 @default.
• W1565332914 hasConceptScore W1565332914C55493867 @default.
• W1565332914 hasConceptScore W1565332914C86803240 @default.
• W1565332914 hasConceptScore W1565332914C95444343 @default.
• W1565332914 hasIssue "30" @default.
• W1565332914 hasLocation W15653329141 @default.
• W1565332914 hasOpenAccess W1565332914 @default.
• W1565332914 hasPrimaryLocation W15653329141 @default.
• W1565332914 hasRelatedWork W1541497469 @default.
• W1565332914 hasRelatedWork W1565332914 @default.
• W1565332914 hasRelatedWork W1973652148 @default.
• W1565332914 hasRelatedWork W2049190231 @default.
• W1565332914 hasRelatedWork W2049755488 @default.
• W1565332914 hasRelatedWork W2062433889 @default.
• W1565332914 hasRelatedWork W2093491041 @default.
• W1565332914 hasRelatedWork W2109187838 @default.

• next