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• W1565348524 abstract "Psoriasis is a chronic dermatosis of presumed autoimmune etiology1 that is characterized by epidermal hyperproliferation and by infiltration of the dermis, epidermis, and stratum corneum by lymphocytes and other inflammatory cells. Activated CD4+ T cells and secreted cytokines, including IFN- (which is elevated in psoriatic lesions) and interleukin-2 (IL-2), have been implicated in disease pathogenesis. Thus, T cells are found in close association with MHC class II+ (HLA-DR+) epidermal Langerhans’ cells (candidate antigen presenting cells).2 Moreover, IFN- has been shown to induce the expression of HLA-DR and adhesion molecules (including intracellular adhesion molecule 1; ICAM-1) on vascular endothelium and epidermal keratinocytes.3 Increased expression of adhesion molecules on these cells promotes the binding of lymphocytes4,5 and may predispose both to the recruitment of T cells into lesional tissue and to their activation.6Cyclosporine A (CyA), an immunomodulatory drug used commonly to prevent graft rejection, inhibits CD4+ T-cell activation, cytokine gene expression, and cytokine production. It is highly effective in the treatment of psoriasis.7 We have shown previously that CyA markedly reduces the T-cell infiltrate within lesional skin, including numbers of IL-2 receptor+ (IL-2R+) cells. This effect is evident within 4 weeks of the start of the therapy.8 However, we also observed the persistence of adhesion molecule expression on lesional vascular endothelium despite resolution of the psoriatic plaques.9 FK 506 is a new immunosuppressive agent with a similar mode of action to CyA.10 It has been shown to be highly effective in the prevention and treatment of organ transplant rejection and has been reported to exhibit fewer side effects than CyA in transplant patients.11,12 Its efficacy in psoriasis has been demonstrated recently in a preliminary study.13In this study we examined immunohistochemical changes within lesional skin of patients with severe recalcitrant psoriasis before and following the instigation of systemic FK 506 therapy. In view of our aforementioned observations concerning CyA, we were interested especially in the influence of FK 506 on T lymphocytes, epidermal Langerhans’ cells, IL-2R-bearing lymphocytes, and the expression of adhesion molecules within lesional skin." @default.
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• W1565348524 date "1991-12-01" @default.
• W1565348524 modified "2023-10-15" @default.
• W1565348524 title "Influence of FK 506 on T lymphocytes, Langerhans' cells and the expression of cytokine receptors and adhesion molecules in psoriatic skin lesions: a preliminary study." @default.
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