FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1565389310> ?p ?o ?g. }

• W1565389310 endingPage "195" @default.
• W1565389310 startingPage "191" @default.
• W1565389310 abstract "Abstract Granulocyte-macrophage colony-stimulating factor (GM-CSF) has previously been shown to stimulate granulocyte, macrophage, and megakaryocyte lineages to act as an erythroid burst-promoting activity and to stimulate limited replication of spleen colony-forming cells. Here we demonstrate that murine GM-CSF alone or in combination with macrophage colony-stimulating factor (CSF-1) can stimulate colony- forming cells in bone marrow (BM) that have a high proliferative capacity. In cultures of BM from mice treated with 5-fluorouracil (FU) eight days before sampling, GM-CSF alone or in combination with CSF-1 stimulated the formation of large macrophage colonies with diameters greater than 0.5 mm. CSF-1 alone, at 800 units or greater, also stimulated larger colonies; however, these colonies were always less than 1.1 mm in diameter, whereas GM-CSF in combination with CSF-1 stimulated many colonies with diameters between 1 and 4 mm. At all doses of CSF-1 tested, the combination of factors resulted in a synergistic increase in colonies with diameters greater than 1.0 or 2.0 mm. Analysis of the incidence of colony-forming cells in the BM of normal mice and mice 2, 4, 6, and 8 days after FU treatment demonstrated that the progenitor cells stimulated by GM-CSF alone or in combination with CSF-1 were depleted by FU treatment in vivo and regenerated more rapidly than did the macrophage progenitors (M-CFC) stimulated by CSF-1 alone. This is similar to the properties of the previously described high-proliferative potential, colony-forming cell (HPP-CFC) that is responsive to interleukin-3 plus CSF-1 but not the HPP-CFC stimulated by hematopoietin 1 plus CSF-1. These data suggest that GM-CSF plus CSF-1 act synergistically to stimulate a population of progenitor cells that have a high proliferative potential and have properties similar to those of the population of HPP-CFC stimulated by interleukin-3 plus CSF-1." @default.
• W1565389310 created "2016-06-24" @default.
• W1565389310 creator A5002550316 @default.
• W1565389310 creator A5031566650 @default.
• W1565389310 creator A5035361443 @default.
• W1565389310 date "1988-07-01" @default.
• W1565389310 modified "2023-10-16" @default.
• W1565389310 title "Stimulation of murine colony-forming cells with high proliferative potential by the combination of GM-CSF and CSF-1" @default.
• W1565389310 cites W101142953 @default.
• W1565389310 cites W1517056268 @default.
• W1565389310 cites W1542735558 @default.
• W1565389310 cites W1732198201 @default.
• W1565389310 cites W2033093905 @default.
• W1565389310 cites W2043757585 @default.
• W1565389310 cites W2097150253 @default.
• W1565389310 cites W2113194264 @default.
• W1565389310 cites W2408307442 @default.
• W1565389310 cites W2414610684 @default.
• W1565389310 cites W2414638541 @default.
• W1565389310 cites W2415024952 @default.
• W1565389310 cites W2415887906 @default.
• W1565389310 cites W2427526893 @default.
• W1565389310 cites W330761805 @default.
• W1565389310 doi "https://doi.org/10.1182/blood.v72.1.191.191" @default.
• W1565389310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3291980" @default.
• W1565389310 hasPublicationYear "1988" @default.
• W1565389310 type Work @default.
• W1565389310 sameAs 1565389310 @default.
• W1565389310 citedByCount "68" @default.
• W1565389310 countsByYear W15653893102013 @default.
• W1565389310 countsByYear W15653893102014 @default.
• W1565389310 crossrefType "journal-article" @default.
• W1565389310 hasAuthorship W1565389310A5002550316 @default.
• W1565389310 hasAuthorship W1565389310A5031566650 @default.
• W1565389310 hasAuthorship W1565389310A5035361443 @default.
• W1565389310 hasBestOaLocation W15653893101 @default.
• W1565389310 hasConcept C109159458 @default.
• W1565389310 hasConcept C134018914 @default.
• W1565389310 hasConcept C14942488 @default.
• W1565389310 hasConcept C150903083 @default.
• W1565389310 hasConcept C153911025 @default.
• W1565389310 hasConcept C201750760 @default.
• W1565389310 hasConcept C202751555 @default.
• W1565389310 hasConcept C203014093 @default.
• W1565389310 hasConcept C207001950 @default.
• W1565389310 hasConcept C24998067 @default.
• W1565389310 hasConcept C2776694085 @default.
• W1565389310 hasConcept C2777478134 @default.
• W1565389310 hasConcept C2777767877 @default.
• W1565389310 hasConcept C2777983669 @default.
• W1565389310 hasConcept C2778690821 @default.
• W1565389310 hasConcept C2779244956 @default.
• W1565389310 hasConcept C2779705218 @default.
• W1565389310 hasConcept C2780007613 @default.
• W1565389310 hasConcept C2780931953 @default.
• W1565389310 hasConcept C28328180 @default.
• W1565389310 hasConcept C50442881 @default.
• W1565389310 hasConcept C54355233 @default.
• W1565389310 hasConcept C55493867 @default.
• W1565389310 hasConcept C64921476 @default.
• W1565389310 hasConcept C86803240 @default.
• W1565389310 hasConcept C880424 @default.
• W1565389310 hasConcept C95444343 @default.
• W1565389310 hasConceptScore W1565389310C109159458 @default.
• W1565389310 hasConceptScore W1565389310C134018914 @default.
• W1565389310 hasConceptScore W1565389310C14942488 @default.
• W1565389310 hasConceptScore W1565389310C150903083 @default.
• W1565389310 hasConceptScore W1565389310C153911025 @default.
• W1565389310 hasConceptScore W1565389310C201750760 @default.
• W1565389310 hasConceptScore W1565389310C202751555 @default.
• W1565389310 hasConceptScore W1565389310C203014093 @default.
• W1565389310 hasConceptScore W1565389310C207001950 @default.
• W1565389310 hasConceptScore W1565389310C24998067 @default.
• W1565389310 hasConceptScore W1565389310C2776694085 @default.
• W1565389310 hasConceptScore W1565389310C2777478134 @default.
• W1565389310 hasConceptScore W1565389310C2777767877 @default.
• W1565389310 hasConceptScore W1565389310C2777983669 @default.
• W1565389310 hasConceptScore W1565389310C2778690821 @default.
• W1565389310 hasConceptScore W1565389310C2779244956 @default.
• W1565389310 hasConceptScore W1565389310C2779705218 @default.
• W1565389310 hasConceptScore W1565389310C2780007613 @default.
• W1565389310 hasConceptScore W1565389310C2780931953 @default.
• W1565389310 hasConceptScore W1565389310C28328180 @default.
• W1565389310 hasConceptScore W1565389310C50442881 @default.
• W1565389310 hasConceptScore W1565389310C54355233 @default.
• W1565389310 hasConceptScore W1565389310C55493867 @default.
• W1565389310 hasConceptScore W1565389310C64921476 @default.
• W1565389310 hasConceptScore W1565389310C86803240 @default.
• W1565389310 hasConceptScore W1565389310C880424 @default.
• W1565389310 hasConceptScore W1565389310C95444343 @default.
• W1565389310 hasIssue "1" @default.
• W1565389310 hasLocation W15653893101 @default.
• W1565389310 hasOpenAccess W1565389310 @default.
• W1565389310 hasPrimaryLocation W15653893101 @default.
• W1565389310 hasRelatedWork W1539055078 @default.
• W1565389310 hasRelatedWork W1692904000 @default.
• W1565389310 hasRelatedWork W2017737576 @default.
• W1565389310 hasRelatedWork W2033470085 @default.

• next