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• W1565394077 endingPage "551" @default.
• W1565394077 startingPage "551" @default.
• W1565394077 abstract "Breast cancer is the most prevalent cancer in women, causing a significant mortality worldwide. Different endocrine strategies are available for the treatment of hormone-sensitive breast cancer, including antiestrogen tamoxifen and fulvestrant, as well as third-generation aromatase inhibitors (AIs), such as letrozole, anastrozole, and exemestane. In this review, we will focus on exemestane, its clinical use, and its side effects. Exemestane is a steroidal third-generation AI now used in all treatment settings for breast cancer. In the metastatic disease, it has been extensively investigated as the first-, second-, and further-line treatment and it is now registered for the treatment of postmenopausal women with advanced estrogen-receptor-positive breast cancer whose disease has progressed following antiestrogen therapy. A potential lack of cross-resistance with nonsteroidal AIs has been described, giving additional therapeutic opportunities in sequences of endocrine agents. Exemestane is also approved for the adjuvant treatment of postmenopausal early breast cancer, either as upfront monotherapy for 5 years, as a switch following 2-3 years of tamoxifen, or as extended therapy beyond 5 years of adjuvant treatment. New promising data also showed a beneficial effect in young premenopausal early breast cancer patients, when administered together with ovarian suppression. Interesting results have also emerged when exemestane has been investigated as neodjuvant treatment as well as preventive agent in healthy women at high risk for breast cancer. Exemestane is generally well tolerated, with a side effect profile similar to that of other AIs, including menopausal symptoms, arthralgia, and bone loss. In conclusion, exemestane can be considered an effective and well-tolerated endocrine treatment option for all stages of breast cancer." @default.
• W1565394077 created "2016-06-24" @default.
• W1565394077 creator A5022372596 @default.
• W1565394077 creator A5030013928 @default.
• W1565394077 creator A5033956695 @default.
• W1565394077 creator A5037113145 @default.
• W1565394077 creator A5063979328 @default.
• W1565394077 creator A5090146115 @default.
• W1565394077 date "2015-05-01" @default.
• W1565394077 modified "2023-09-23" @default.
• W1565394077 title "Clinical utility of exemestane in the treatment of&nbsp;breast cancer&nbsp;" @default.
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