FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1565403166> ?p ?o ?g. }

• W1565403166 endingPage "3048" @default.
• W1565403166 startingPage "3042" @default.
• W1565403166 abstract "Antigen ganglioside GD2 is expressed abundantly on neuroblastoma (NB) cells. Anti-GD2 monoclonal antibody (MoAb) 3F8 kills NB cells by complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity. Its utility in bone marrow (BM) purging is evaluated by a real-time reverse transcription-polymerase chain reaction (RT-PCR) assay to quantify the mRNA of GD2 synthase, the key enzyme in GD2 synthesis.From 1990 to 1993, 10 patients with relapsed/refractory Stage 4 NB participated in a pilot study. In these patients, MoAb 3F8 was used to purge tumor cells from harvested BM that had 5% or less tumor content by immunofluorescence (IF). Subsequently, 31 Stage 4 NB patients who underwent treatment on the N7 protocol (1994-1999) had their BM, which was in remission, purged by 3F8 before (131)I-3F8 myeloablative radioimmunotherapy. GD2-positive tumor cells before and after purging were quantified by real-time quantitative RT-PCR of GD2 synthase.GD2 positivity by IF was found before purging in six of eight patients in the pilot study. Five of six patients became negative postpurging. Of 31 patients on the N7 protocol, the more sensitive real-time quantitative RT-PCR detected GD2 synthase mRNA in the BM samples of 7 patients even though the prepurge BM samples were negative by histology and IF. Six of the seven BM samples became negative after 3F8 purging. Marker positivity before purging was statistically significant in predicting overall survival (P = 0.04), but not progression-free survival (P = 0.1). In vitro hematopoietic stem cell recovery and the median time to engraftment were acceptable.Tumor cell depletion quantified by real-time RT-PCR demonstrated efficacy of MoAb 3F8 in BM purging." @default.
• W1565403166 created "2016-06-24" @default.
• W1565403166 creator A5007786900 @default.
• W1565403166 creator A5034081882 @default.
• W1565403166 creator A5043729995 @default.
• W1565403166 creator A5060645426 @default.
• W1565403166 creator A5083817841 @default.
• W1565403166 date "2002-05-23" @default.
• W1565403166 modified "2023-09-28" @default.
• W1565403166 title "Quantitation of GD2 synthase mRNA by real-time reverse transcription-polymerase chain reaction" @default.
• W1565403166 cites W1220071306 @default.
• W1565403166 cites W1575002436 @default.
• W1565403166 cites W1821283949 @default.
• W1565403166 cites W1831803445 @default.
• W1565403166 cites W1898762201 @default.
• W1565403166 cites W1951179504 @default.
• W1565403166 cites W1965571092 @default.
• W1565403166 cites W1966151215 @default.
• W1565403166 cites W1966474027 @default.
• W1565403166 cites W1968706708 @default.
• W1565403166 cites W1972953239 @default.
• W1565403166 cites W1998347916 @default.
• W1565403166 cites W1999514952 @default.
• W1565403166 cites W2031726826 @default.
• W1565403166 cites W2039990819 @default.
• W1565403166 cites W2046628826 @default.
• W1565403166 cites W2068441417 @default.
• W1565403166 cites W2087396775 @default.
• W1565403166 cites W2107206076 @default.
• W1565403166 cites W2137017579 @default.
• W1565403166 cites W2140591503 @default.
• W1565403166 cites W2162992800 @default.
• W1565403166 cites W2231776808 @default.
• W1565403166 cites W2242711566 @default.
• W1565403166 cites W2246281708 @default.
• W1565403166 cites W2280912529 @default.
• W1565403166 cites W2324582862 @default.
• W1565403166 cites W2327522594 @default.
• W1565403166 cites W2339392195 @default.
• W1565403166 cites W4247172039 @default.
• W1565403166 doi "https://doi.org/10.1002/cncr.10519" @default.
• W1565403166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12115395" @default.
• W1565403166 hasPublicationYear "2002" @default.
• W1565403166 type Work @default.
• W1565403166 sameAs 1565403166 @default.
• W1565403166 citedByCount "21" @default.
• W1565403166 countsByYear W15654031662014 @default.
• W1565403166 countsByYear W15654031662022 @default.
• W1565403166 crossrefType "journal-article" @default.
• W1565403166 hasAuthorship W1565403166A5007786900 @default.
• W1565403166 hasAuthorship W1565403166A5034081882 @default.
• W1565403166 hasAuthorship W1565403166A5043729995 @default.
• W1565403166 hasAuthorship W1565403166A5060645426 @default.
• W1565403166 hasAuthorship W1565403166A5083817841 @default.
• W1565403166 hasConcept C104317684 @default.
• W1565403166 hasConcept C105580179 @default.
• W1565403166 hasConcept C142724271 @default.
• W1565403166 hasConcept C147483822 @default.
• W1565403166 hasConcept C153911025 @default.
• W1565403166 hasConcept C159654299 @default.
• W1565403166 hasConcept C203014093 @default.
• W1565403166 hasConcept C2776715637 @default.
• W1565403166 hasConcept C2780007613 @default.
• W1565403166 hasConcept C4692481 @default.
• W1565403166 hasConcept C542903549 @default.
• W1565403166 hasConcept C54355233 @default.
• W1565403166 hasConcept C55493867 @default.
• W1565403166 hasConcept C71924100 @default.
• W1565403166 hasConcept C81885089 @default.
• W1565403166 hasConcept C86803240 @default.
• W1565403166 hasConceptScore W1565403166C104317684 @default.
• W1565403166 hasConceptScore W1565403166C105580179 @default.
• W1565403166 hasConceptScore W1565403166C142724271 @default.
• W1565403166 hasConceptScore W1565403166C147483822 @default.
• W1565403166 hasConceptScore W1565403166C153911025 @default.
• W1565403166 hasConceptScore W1565403166C159654299 @default.
• W1565403166 hasConceptScore W1565403166C203014093 @default.
• W1565403166 hasConceptScore W1565403166C2776715637 @default.
• W1565403166 hasConceptScore W1565403166C2780007613 @default.
• W1565403166 hasConceptScore W1565403166C4692481 @default.
• W1565403166 hasConceptScore W1565403166C542903549 @default.
• W1565403166 hasConceptScore W1565403166C54355233 @default.
• W1565403166 hasConceptScore W1565403166C55493867 @default.
• W1565403166 hasConceptScore W1565403166C71924100 @default.
• W1565403166 hasConceptScore W1565403166C81885089 @default.
• W1565403166 hasConceptScore W1565403166C86803240 @default.
• W1565403166 hasIssue "11" @default.
• W1565403166 hasLocation W15654031661 @default.
• W1565403166 hasLocation W15654031662 @default.
• W1565403166 hasOpenAccess W1565403166 @default.
• W1565403166 hasPrimaryLocation W15654031661 @default.
• W1565403166 hasRelatedWork W1943797027 @default.
• W1565403166 hasRelatedWork W1997716688 @default.
• W1565403166 hasRelatedWork W1998831848 @default.
• W1565403166 hasRelatedWork W2029145496 @default.
• W1565403166 hasRelatedWork W2037509311 @default.
• W1565403166 hasRelatedWork W2038126255 @default.
• W1565403166 hasRelatedWork W2064089409 @default.

• next