Matches in SemOpenAlex for { <https://semopenalex.org/work/W1565550113> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1565550113 endingPage "781" @default.
- W1565550113 startingPage "767" @default.
- W1565550113 abstract "This chapter describes the basic statistical thermodynamic formalism required to interpret hydrogen exchange protection factors. The agreement between predicted and experimental hydrogen exchange protection factors for staphylococcal nuclease (SNase) and other proteins suggests that the probability distribution of partially folded states generated with the COREX algorithm mimics the general features of the ensemble of conformations under native conditions and that this approach can be used to examine general aspects of the equilibrium ensemble of partially folded states. It has also been shown that this approach accounts for the cooperativity of folding/unfolding transitions and successfully predicts the apparent two-state behavior observed in temperature and denaturant induced folding/unfolding reactions. The folding/unfolding equilibrium of proteins as observed by global macroscopic observables can be usually described by simple models, including two, three, or at most a few conformational states. The situation is different when the equilibrium is studied by physical observables that monitor the behavior of individual residues. It is possible for some residues to exhibit high stability constants or protection factors and simultaneously m values close to zero. This behavior should be contrasted with that expected for the logarithm of a two-state equilibrium constant that should be linear with denaturant concentration." @default.
- W1565550113 created "2016-06-24" @default.
- W1565550113 creator A5007948012 @default.
- W1565550113 creator A5023619981 @default.
- W1565550113 date "1997-01-01" @default.
- W1565550113 modified "2023-10-15" @default.
- W1565550113 title "The equilibrium ensemble of conformational states in staphylococcal nuclease" @default.
- W1565550113 cites W1496368635 @default.
- W1565550113 cites W1964542667 @default.
- W1565550113 cites W1969875263 @default.
- W1565550113 cites W1979038840 @default.
- W1565550113 cites W1987711796 @default.
- W1565550113 cites W2025874401 @default.
- W1565550113 cites W2029513865 @default.
- W1565550113 cites W2030750487 @default.
- W1565550113 cites W2044397014 @default.
- W1565550113 cites W2053129848 @default.
- W1565550113 cites W2058708926 @default.
- W1565550113 cites W2060528711 @default.
- W1565550113 cites W2071659750 @default.
- W1565550113 cites W2073185240 @default.
- W1565550113 cites W2074991560 @default.
- W1565550113 cites W2079606633 @default.
- W1565550113 cites W2080736062 @default.
- W1565550113 cites W2080987790 @default.
- W1565550113 cites W2114320763 @default.
- W1565550113 cites W2132057492 @default.
- W1565550113 cites W2136489728 @default.
- W1565550113 cites W2198115699 @default.
- W1565550113 doi "https://doi.org/10.1016/s1080-8914(97)80075-0" @default.
- W1565550113 hasPublicationYear "1997" @default.
- W1565550113 type Work @default.
- W1565550113 sameAs 1565550113 @default.
- W1565550113 citedByCount "1" @default.
- W1565550113 crossrefType "book-chapter" @default.
- W1565550113 hasAuthorship W1565550113A5007948012 @default.
- W1565550113 hasAuthorship W1565550113A5023619981 @default.
- W1565550113 hasBestOaLocation W15655501131 @default.
- W1565550113 hasConcept C10710636 @default.
- W1565550113 hasConcept C119599485 @default.
- W1565550113 hasConcept C121332964 @default.
- W1565550113 hasConcept C121864883 @default.
- W1565550113 hasConcept C127413603 @default.
- W1565550113 hasConcept C134306372 @default.
- W1565550113 hasConcept C147789679 @default.
- W1565550113 hasConcept C166014724 @default.
- W1565550113 hasConcept C185592680 @default.
- W1565550113 hasConcept C204328495 @default.
- W1565550113 hasConcept C2776545253 @default.
- W1565550113 hasConcept C32848918 @default.
- W1565550113 hasConcept C33923547 @default.
- W1565550113 hasConcept C39927690 @default.
- W1565550113 hasConcept C55493867 @default.
- W1565550113 hasConcept C62520636 @default.
- W1565550113 hasConcept C97355855 @default.
- W1565550113 hasConceptScore W1565550113C10710636 @default.
- W1565550113 hasConceptScore W1565550113C119599485 @default.
- W1565550113 hasConceptScore W1565550113C121332964 @default.
- W1565550113 hasConceptScore W1565550113C121864883 @default.
- W1565550113 hasConceptScore W1565550113C127413603 @default.
- W1565550113 hasConceptScore W1565550113C134306372 @default.
- W1565550113 hasConceptScore W1565550113C147789679 @default.
- W1565550113 hasConceptScore W1565550113C166014724 @default.
- W1565550113 hasConceptScore W1565550113C185592680 @default.
- W1565550113 hasConceptScore W1565550113C204328495 @default.
- W1565550113 hasConceptScore W1565550113C2776545253 @default.
- W1565550113 hasConceptScore W1565550113C32848918 @default.
- W1565550113 hasConceptScore W1565550113C33923547 @default.
- W1565550113 hasConceptScore W1565550113C39927690 @default.
- W1565550113 hasConceptScore W1565550113C55493867 @default.
- W1565550113 hasConceptScore W1565550113C62520636 @default.
- W1565550113 hasConceptScore W1565550113C97355855 @default.
- W1565550113 hasLocation W15655501131 @default.
- W1565550113 hasOpenAccess W1565550113 @default.
- W1565550113 hasPrimaryLocation W15655501131 @default.
- W1565550113 hasRelatedWork W1565550113 @default.
- W1565550113 hasRelatedWork W170429052 @default.
- W1565550113 hasRelatedWork W1971989572 @default.
- W1565550113 hasRelatedWork W2004644004 @default.
- W1565550113 hasRelatedWork W2008494223 @default.
- W1565550113 hasRelatedWork W2032978678 @default.
- W1565550113 hasRelatedWork W2181625855 @default.
- W1565550113 hasRelatedWork W2964039158 @default.
- W1565550113 hasRelatedWork W3103004834 @default.
- W1565550113 hasRelatedWork W4298183151 @default.
- W1565550113 isParatext "false" @default.
- W1565550113 isRetracted "false" @default.
- W1565550113 magId "1565550113" @default.
- W1565550113 workType "book-chapter" @default.