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- W1565552468 abstract "Abstract Earlier investigations have shown that DNA synthesis in rabbit kidney cortex cells cultured directly from the animal begins after a 30- to 40-hour lag period, and that an apparently related event in the life history of these cells is a relatively abrupt doubling in the over-all rate of RNA synthesis midway through this lag period. The nature of the RNA synthesized at different times during the lag period has now been investigated by sucrose gradient sedimentation analysis. After a 1-hour exposure to 3H-uridine, most of the labeled RNA is located in the nucleus. In cells that have been in culture for 9 hours or less, a large proportion of the RNA labeled in this way is heterodisperse in sedimentation properties. After 25 hours in culture, when the RNA synthesis rate has doubled, the pattern of labeled RNA is characterized by a greatly increased proportion of 45 S and 32 S ribosomal RNA precursor. During a 4-hour chase with unlabeled uridine and actinomycin D, these nuclear precursors are converted to 28 S and 18 S ribosomal RNA, and are transported to the cytoplasm. Little change occurs in the level of nuclear heterodisperse RNA at any time during the first 40 hours in culture. Thus, the increase in rate of RNA synthesis occurring during the period preceding DNA replication is primarily due to a considerable acceleration of ribosome production." @default.
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- W1565552468 date "1970-09-01" @default.
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- W1565552468 title "Nature of the Ribonucleic Acid Formed Prior to Deoxyribonucleic Acid Synthesis in Kidney Cortex Cells Cultured Directly from the Rabbit" @default.
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- W1565552468 doi "https://doi.org/10.1016/s0021-9258(19)63822-6" @default.
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