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- W1565570745 abstract "Two fetal-specific serum antigens were demonstrated in fetal mouse protein extracts and in newborn serum when examined by immunodiffusion with antiserum to fetal extract. After dilution of the antiserum, microcomplement fixation assay was specific for one of these antigens. This antigen had the electrophoretic mobility of an α1-globulin and a molecular weight of 65,000 to 70,000. Synthesis of α1 fetal antigen begins on or before the 10th day of gestation; the total amount rises to a maximum at 20 days of gestation and falls sharply after birth. α1 fetal antigen is not present in adult serum in concentrations greater than 0.0025% that of newborn serum. Synthesis of α1 antigen is resumed in adult mice bearing transplantable hepatoma and teratoma tumors. A clonal in vitro line of testicular teratocarcinoma was found to synthesize α1 fetal antigen. α1 fetal antigens synthesized by perinatal mice, hepatomas, and undifferentiated teratoma cells are serologically identical." @default.
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- W1565570745 date "1971-07-01" @default.
- W1565570745 modified "2023-10-17" @default.
- W1565570745 title "The occurrence of a serum fetal alpha-1 protein in developing mice and murine hepatomas and teratomas." @default.
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