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• W1565584672 abstract "The type 1 cannabinoid receptor (CB(1) ) is an integral component of the endocannabinoid system that modulates several functions in the CNS and periphery. The majority of our knowledge of the endocannabinoid system involves ligand-receptor binding, mechanisms of signal transduction, and protein-protein interactions. In contrast, comparatively little is known about regulation of CB(1) gene expression. The levels and anatomical distribution of CB(1) mRNA and protein are developmental stage-specific and are dysregulated in several pathological conditions. Moreover, exposure to a variety of drugs, including cannabinoids themselves, alters CB(1) gene expression and mRNA levels. As such, alterations in CB(1) gene expression are likely to affect the optimal response to cannabinoid-based therapies, which are being developed to treat a growing number of conditions. Here, we will examine the regulation of CB(1) mRNA levels and the therapeutic potential inherent in manipulating expression of this gene.This article is part of a themed section on Cannabinoids. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.167.issue-8." @default.
• W1565584672 created "2016-06-24" @default.
• W1565584672 creator A5037819900 @default.
• W1565584672 creator A5063933580 @default.
• W1565584672 creator A5088113414 @default.
• W1565584672 date "2012-11-29" @default.
• W1565584672 modified "2023-10-14" @default.
• W1565584672 title "The dynamic nature of type 1 cannabinoid receptor (CB₁) gene transcription" @default.
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• W1565584672 doi "https://doi.org/10.1111/j.1476-5381.2012.02175.x" @default.
• W1565584672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3525862" @default.
• W1565584672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22924606" @default.
• W1565584672 hasPublicationYear "2012" @default.
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