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• W1565603180 abstract "Silencing Amblyomma americanum insulin-like growth factor binding protein-related protein 1 (AamIGFBP-rP1) mRNA prevented ticks from feeding to repletion. In this study, we used recombinant (r)AamIGFBP-rP1 in a series of assays to obtain further insight into the role(s) of this protein in tick feeding regulation. Our results suggest that AamIGFBP-1 is an antigenic protein that is apparently exclusively expressed in salivary glands. We found that both males and females secrete AamIGFBP-rP1 into the host during feeding and confirmed that female ticks secrete this protein from within 24-48 h after attachment. Our data suggest that native AamIGFBP-rP1 is a functional insulin binding protein in that both yeast- and insect cell-expressed rAamIGFBP-rP1 bound insulin, but not insulin-like growth factors. When subjected to anti-blood clotting and platelet aggregation assays, rAamIGFBP-rP1 did not have any effect. Unlike human IGFBP-rP1, which is controlled by trypsinization, rAamIGFBP-rP1 is resistant to digestion, suggesting that the tick protein may not be under mammalian host control at the tick feeding site. The majority of tick-borne pathogens are transmitted 48 h after the tick has attached. Thus, the demonstrated antigenicity and secretion into the host within 24-48 h of the tick starting to feed makes AamIGFBP-rP1 an attractive target for antitick vaccine development." @default.
• W1565603180 created "2016-06-24" @default.
• W1565603180 creator A5020921372 @default.
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• W1565603180 creator A5067181641 @default.
• W1565603180 creator A5082591435 @default.
• W1565603180 date "2015-06-25" @default.
• W1565603180 modified "2023-10-04" @default.
• W1565603180 title "<i>Amblyomma americanum</i>tick saliva insulin-like growth factor binding protein-related protein 1 binds insulin but not insulin-like growth factors" @default.
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• W1565603180 doi "https://doi.org/10.1111/imb.12180" @default.
• W1565603180 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4560673" @default.
• W1565603180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26108887" @default.
• W1565603180 hasPublicationYear "2015" @default.
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