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- W1565631409 abstract "The Pol II transcription cycle can be divided into three main phases: transcription initiation, elongation and termination. Each phase represent a possibility for the regulation of gene expression. Recently, genome-wide studies demonstrated that Pol II pausing is an important regulatory step that is present at almost every eukaryotic Pol II promoter. Surprisingly, paused or slowed down polymerases were also discovered downstream of 3’ end of genes, of which the exact role is still not fully understood.During my Ph.D. I carried out projects using chromatin immunoprecipitation assay coupled to high-throughput sequencing techniques to analyze genome-wide Pol II behavior in two aspects:First, we analyzed Pol II occupancy downstream of 3’ end of transcription units. Our analyses suggest that accumulation of Pol II downstream of genes is a genome-wide feature of active transcription. We found broad, often up to 6kb long Pol II occupancy signals at genes coding for polyadenylated transcripts. In contrast, Pol II occupancy shows a narrow profile at the annotated end of core histone genes. We also found a link between RNA 3’ end processing and Pol II accumulation at the end of transcription units.Second, we were following the genome-wide response and alteration of Pol II transcription upon genotoxic stress. Following UV-B treatment we observed a progressive Pol II signal loss from the promoters of expressed genes, which will then extend through the entire transcription unit, up to four hours after irradiation. This is in good agreement with the observation that after UV irradiation transcription is arrested during the period of transcription-coupled repair (TCR)." @default.
- W1565631409 created "2016-06-24" @default.
- W1565631409 creator A5079395187 @default.
- W1565631409 date "2012-12-19" @default.
- W1565631409 modified "2023-10-17" @default.
- W1565631409 title "Genome-wide characterization of RNA polymerase II behavior during transcription termination and upon UV-B stress" @default.
- W1565631409 hasPublicationYear "2012" @default.
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