Matches in SemOpenAlex for { <https://semopenalex.org/work/W1565654706> ?p ?o ?g. }
- W1565654706 endingPage "110" @default.
- W1565654706 startingPage "101" @default.
- W1565654706 abstract "Nerve growth factor (NGF) acts on various classes of central and peripheral neurons to promote cell survival, stimulate neurite outgrowth and modulate differentiation. NGF is synthesized as a precursor, proNGF, which undergoes processing to generate mature NGF. It has been assumed, based on studies in the mouse submandibular gland, that NGF in vivo is largely mature NGF, and that mature NGF accounts for the molecule's biological activity. However, recently we have shown that proNGF is abundant in central nervous system tissues whereas mature NGF is undetectable, suggesting that proNGF may have a function distinct from its role as a precursor. A recent report that proNGF has apoptotic activity contrasts with other data demonstrating that proNGF has neurotrophic activity. This chapter will review the structure and processing of NGF and what is known about the biological activity of proNGF. Possible reasons for the discrepancies in recent reports are discussed." @default.
- W1565654706 created "2016-06-24" @default.
- W1565654706 creator A5043600072 @default.
- W1565654706 creator A5045710219 @default.
- W1565654706 creator A5077083856 @default.
- W1565654706 date "2004-01-01" @default.
- W1565654706 modified "2023-10-08" @default.
- W1565654706 title "ProNGF: a neurotrophic or an apoptotic molecule?" @default.
- W1565654706 cites W1509043648 @default.
- W1565654706 cites W1509595611 @default.
- W1565654706 cites W1511063261 @default.
- W1565654706 cites W1514323236 @default.
- W1565654706 cites W1551863855 @default.
- W1565654706 cites W1590264526 @default.
- W1565654706 cites W1593538742 @default.
- W1565654706 cites W1753428747 @default.
- W1565654706 cites W1754916819 @default.
- W1565654706 cites W176331650 @default.
- W1565654706 cites W1842900458 @default.
- W1565654706 cites W1877097897 @default.
- W1565654706 cites W1880716631 @default.
- W1565654706 cites W1946506165 @default.
- W1565654706 cites W1963541881 @default.
- W1565654706 cites W1964325390 @default.
- W1565654706 cites W1971369064 @default.
- W1565654706 cites W1974093403 @default.
- W1565654706 cites W1975262598 @default.
- W1565654706 cites W1983535845 @default.
- W1565654706 cites W1984872480 @default.
- W1565654706 cites W1991624956 @default.
- W1565654706 cites W2000922276 @default.
- W1565654706 cites W2003378719 @default.
- W1565654706 cites W2003522028 @default.
- W1565654706 cites W2006021010 @default.
- W1565654706 cites W2006747031 @default.
- W1565654706 cites W2008928624 @default.
- W1565654706 cites W2016764535 @default.
- W1565654706 cites W2017231139 @default.
- W1565654706 cites W2017575606 @default.
- W1565654706 cites W2018442081 @default.
- W1565654706 cites W2020181126 @default.
- W1565654706 cites W2025861142 @default.
- W1565654706 cites W2033235067 @default.
- W1565654706 cites W2033799925 @default.
- W1565654706 cites W2041238731 @default.
- W1565654706 cites W2049404940 @default.
- W1565654706 cites W2049809617 @default.
- W1565654706 cites W2051127195 @default.
- W1565654706 cites W2055536996 @default.
- W1565654706 cites W2059935802 @default.
- W1565654706 cites W2060279082 @default.
- W1565654706 cites W2066068720 @default.
- W1565654706 cites W2069537854 @default.
- W1565654706 cites W2070712835 @default.
- W1565654706 cites W2078116878 @default.
- W1565654706 cites W2083439934 @default.
- W1565654706 cites W2087090756 @default.
- W1565654706 cites W2087803797 @default.
- W1565654706 cites W2091024750 @default.
- W1565654706 cites W2091720251 @default.
- W1565654706 cites W2092165212 @default.
- W1565654706 cites W2102240673 @default.
- W1565654706 cites W2113429450 @default.
- W1565654706 cites W2114216374 @default.
- W1565654706 cites W2118813298 @default.
- W1565654706 cites W2119326933 @default.
- W1565654706 cites W2123297155 @default.
- W1565654706 cites W2128960139 @default.
- W1565654706 cites W2129991279 @default.
- W1565654706 cites W2132590272 @default.
- W1565654706 cites W2168614774 @default.
- W1565654706 cites W221084160 @default.
- W1565654706 cites W3105898142 @default.
- W1565654706 cites W47943911 @default.
- W1565654706 doi "https://doi.org/10.1016/s0079-6123(03)46007-x" @default.
- W1565654706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14699959" @default.
- W1565654706 hasPublicationYear "2004" @default.
- W1565654706 type Work @default.
- W1565654706 sameAs 1565654706 @default.
- W1565654706 citedByCount "105" @default.
- W1565654706 countsByYear W15656547062012 @default.
- W1565654706 countsByYear W15656547062013 @default.
- W1565654706 countsByYear W15656547062014 @default.
- W1565654706 countsByYear W15656547062015 @default.
- W1565654706 countsByYear W15656547062016 @default.
- W1565654706 countsByYear W15656547062017 @default.
- W1565654706 countsByYear W15656547062018 @default.
- W1565654706 countsByYear W15656547062019 @default.
- W1565654706 countsByYear W15656547062020 @default.
- W1565654706 countsByYear W15656547062021 @default.
- W1565654706 countsByYear W15656547062022 @default.
- W1565654706 countsByYear W15656547062023 @default.
- W1565654706 crossrefType "book-chapter" @default.
- W1565654706 hasAuthorship W1565654706A5043600072 @default.
- W1565654706 hasAuthorship W1565654706A5045710219 @default.
- W1565654706 hasAuthorship W1565654706A5077083856 @default.
- W1565654706 hasConcept C113246987 @default.
- W1565654706 hasConcept C126322002 @default.