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• W1565668056 abstract "Bone regulating systems have received growing attention in recent years. Regulation of skeletal pathophysiology and modulation of osteoblast, osteoclast and osteocyte activity by hormones, cytokines, and growth factors are not only important features of bone biology, but also a target for old and new osteoporosis therapies.Molecules such as selective estrogen receptor modulators (SERMs, e.g. raloxifene and bazedoxifene), denosumab, or bisphosphonates may exert their effects through modulation of estrogen receptor, RANKL and osteoclast activity, respectively. Knowledge of the regulating systems is also the basis for developing future therapy. This review shows regulating systems as a basis for current and future therapies in the field of osteoporosis" @default.
• W1565668056 created "2016-06-24" @default.
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• W1565668056 date "2012-01-01" @default.
• W1565668056 modified "2023-09-27" @default.
• W1565668056 title "Bone tissue: hormonal regulating systems, growth factors and remodeling as a target for therapeutic agents in osteoporosis" @default.
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