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• W1565673931 abstract "Neuroblastoma (NB) is a childhood tumor derived from sympathoadreanal lineage of the neural crest progenitor cells, and is the most common malignant disease of infancy, accounting for 96% of cases occurred before the age of 10 (Gurney et al., 1995, Maris and Matthay, 1999). The neuroblastoma cells exhibit characteristics of undifferentiated cells and often metastasize to distant organs (Maris and Matthay, 1999, Maris et al., 2007). Approximately, 60% of patients diagnosed with NB display a stage IV disease and a very poor prognosis. The 5-year survival rate of NB patients is no more than 30%, even with aggressive therapy (Nishihira et al., 2000). As a result, 50% of the NB patients die from this disease that continues to be one of the most difficult challenges among pediatric tumors. NB is quite a heterogeneous tumor and presents a broad clinical and biologic spectrum ranging from highly undifferentiated tumors with very poor outcomes to the most differentiated benign ganglioneuroma or NBs with high probability of spontaneous regression and hence favorable prognosis. The clinical presentation of NB can be categorized into three distinct patterns based on the tumor histology: (i) life-threatening progression; (ii) maturation to ganglioneuroblastoma (GNB) or ganglioneuroma (GN); and (iii) spontaneous regression (Pritchard and Hickman, 1994). Taking other biological variables into account, NBs can be categorized into two groups in terms of prognosis (Brodeur, 2003, Woods et al., 1992). One, the favorable NB, is associated with young age and" @default.
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• W1565673931 date "2012-02-08" @default.
• W1565673931 modified "2023-09-27" @default.
• W1565673931 title "Molecular Chaperones as Prognostic Markers of Neuroblastoma" @default.
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• W1565673931 doi "https://doi.org/10.5772/28227" @default.
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