FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1565732077> ?p ?o ?g. }

• W1565732077 endingPage "6615" @default.
• W1565732077 startingPage "6608" @default.
• W1565732077 abstract "Adoptive immunotherapy with cyclophosphamide (Cy) increases the host resistance against tumor growth. The precise mechanism(s) by which this therapy enhances tumor suppression is unclear. Cy induces the development of early myeloid cells that may be strongly antiproliferative through NO production. These cells are similar to the natural suppressor cells found in normal bone marrow with a potential antitumor effect. Here we have addressed whether the development of NO-producing cells may be involved in this tumor resistance in Cy-treated mice. The results show a synergism between Cy treatment and tumor-specific lymphocytes transferred systemically (i.v.) or locally (Winn's assay) that results in a strong tumor suppression. Inhibition of NO production by N(G)-monomethyl-L-arginine at the site of tumor inoculation results in a loss of the protection achieved by the combined therapy. Cy-treated mice develop splenic early myeloid (CD11b, Gr-1, CD31 (ER-MP12), ER-MP20, ER-MP54) cells producing large amounts of NO upon T cell-derived signals (IFN-gamma plus CD40 ligation) able to inhibit tumor cell growth in vitro. Early myeloid cells (ER-MP54(+)) and cells expressing inducible NO synthase are increased at the site of tumor challenge in mice treated with the combined therapy, but not in those treated with Cy or immune cell transfer alone. Thus, Cy induces the expansion of early myeloid cells, inhibiting tumor cell growth by a mechanism involving NO. Both the recruitment and the activation of these myeloid cells at the site of tumor challenge appear to be dependent on the presence of tumor-specific lymphocytes." @default.
• W1565732077 created "2016-06-24" @default.
• W1565732077 creator A5011816951 @default.
• W1565732077 creator A5044711362 @default.
• W1565732077 creator A5072053477 @default.
• W1565732077 creator A5080220887 @default.
• W1565732077 date "2001-06-01" @default.
• W1565732077 modified "2023-09-26" @default.
• W1565732077 title "Cyclophosphamide Induces the Development of Early Myeloid Cells Suppressing Tumor Cell Growth by a Nitric Oxide-Dependent Mechanism" @default.
• W1565732077 cites W1444462873 @default.
• W1565732077 cites W1489678151 @default.
• W1565732077 cites W1500094754 @default.
• W1565732077 cites W1554367074 @default.
• W1565732077 cites W1572267688 @default.
• W1565732077 cites W1887472438 @default.
• W1565732077 cites W1903933791 @default.
• W1565732077 cites W1915878170 @default.
• W1565732077 cites W1921114390 @default.
• W1565732077 cites W1936959276 @default.
• W1565732077 cites W1942232650 @default.
• W1565732077 cites W1968081418 @default.
• W1565732077 cites W1971754021 @default.
• W1565732077 cites W1972118176 @default.
• W1565732077 cites W1988170566 @default.
• W1565732077 cites W1990689075 @default.
• W1565732077 cites W2004854221 @default.
• W1565732077 cites W2009427332 @default.
• W1565732077 cites W2025354151 @default.
• W1565732077 cites W2025535787 @default.
• W1565732077 cites W2033880174 @default.
• W1565732077 cites W2035672119 @default.
• W1565732077 cites W2036143347 @default.
• W1565732077 cites W2036262856 @default.
• W1565732077 cites W2043177369 @default.
• W1565732077 cites W2047203592 @default.
• W1565732077 cites W2049599010 @default.
• W1565732077 cites W2053928386 @default.
• W1565732077 cites W2055475029 @default.
• W1565732077 cites W2056664344 @default.
• W1565732077 cites W2057025197 @default.
• W1565732077 cites W2061952839 @default.
• W1565732077 cites W2064197612 @default.
• W1565732077 cites W2065195389 @default.
• W1565732077 cites W2065930081 @default.
• W1565732077 cites W2070771917 @default.
• W1565732077 cites W2084920222 @default.
• W1565732077 cites W2087919417 @default.
• W1565732077 cites W2091123006 @default.
• W1565732077 cites W2095925250 @default.
• W1565732077 cites W2131786833 @default.
• W1565732077 cites W2148687063 @default.
• W1565732077 cites W2166519885 @default.
• W1565732077 cites W2168200596 @default.
• W1565732077 cites W2172845396 @default.
• W1565732077 cites W2252334125 @default.
• W1565732077 cites W2368290810 @default.
• W1565732077 cites W4241405539 @default.
• W1565732077 cites W4254870277 @default.
• W1565732077 cites W4296792904 @default.
• W1565732077 cites W49463148 @default.
• W1565732077 cites W64123742 @default.
• W1565732077 cites W85451257 @default.
• W1565732077 doi "https://doi.org/10.4049/jimmunol.166.11.6608" @default.
• W1565732077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11359814" @default.
• W1565732077 hasPublicationYear "2001" @default.
• W1565732077 type Work @default.
• W1565732077 sameAs 1565732077 @default.
• W1565732077 citedByCount "87" @default.
• W1565732077 countsByYear W15657320772012 @default.
• W1565732077 countsByYear W15657320772013 @default.
• W1565732077 countsByYear W15657320772014 @default.
• W1565732077 countsByYear W15657320772015 @default.
• W1565732077 countsByYear W15657320772016 @default.
• W1565732077 countsByYear W15657320772017 @default.
• W1565732077 countsByYear W15657320772018 @default.
• W1565732077 countsByYear W15657320772019 @default.
• W1565732077 countsByYear W15657320772020 @default.
• W1565732077 countsByYear W15657320772021 @default.
• W1565732077 countsByYear W15657320772022 @default.
• W1565732077 crossrefType "journal-article" @default.
• W1565732077 hasAuthorship W1565732077A5011816951 @default.
• W1565732077 hasAuthorship W1565732077A5044711362 @default.
• W1565732077 hasAuthorship W1565732077A5072053477 @default.
• W1565732077 hasAuthorship W1565732077A5080220887 @default.
• W1565732077 hasBestOaLocation W15657320771 @default.
• W1565732077 hasConcept C104317684 @default.
• W1565732077 hasConcept C179185449 @default.
• W1565732077 hasConcept C185592680 @default.
• W1565732077 hasConcept C203014093 @default.
• W1565732077 hasConcept C2776090121 @default.
• W1565732077 hasConcept C2779282312 @default.
• W1565732077 hasConcept C502942594 @default.
• W1565732077 hasConcept C55493867 @default.
• W1565732077 hasConcept C55721878 @default.
• W1565732077 hasConcept C86803240 @default.
• W1565732077 hasConcept C8891405 @default.
• W1565732077 hasConcept C90375314 @default.
• W1565732077 hasConceptScore W1565732077C104317684 @default.

• next