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- W1565769935 abstract "Low-density lipoprotein cholesterol (LDL-C) apheresis is an effective therapy to reduce CVD risk in hypercholesterolemic patients who are refractory or intolerant to lipid-lowering therapy. We hypothesized that a single treatment of LDL-C apheresis would increase vascular endothelial function by decreasing oxidative stress responses that limit nitric oxide (NO) bioavailability. Patients (n=5; 52±11 y) were actively receiving bi-weekly LDL-C apheresis treatments (duration=54±41 mo). Brachial artery flow-mediated dilation (FMD), plasma lipids, vitamin E (α- and γ-tocopherol), markers of oxidative stress (nitro-γ-tocopherol, malondialdehyde (MDA)), and regulators of NO metabolism (arginine (ARG), asymmetric dimethylarginine (ADMA)) were assessed prior to (Pre) and immediately following LDL-C apheresis (Post) and at 1, 3, 7, and 14 d Post. Relative to Pre, total C (300±58 mg/dL) and LDL-C (239±46 mg/dL) at Post were 61% and 70% lower (P<0.01), respectively, and remained 46-56%, 27-34%, and 14-16% lower at 1, 3, and 7 d, respectively. Plasma α-, γ-, and nitro-γ-tocopherol concentrations were 52-69% lower at Post (P<0.01), and α-tocopherol remained 36% lower at 1 d while nitro-γ-tocopherol remained 41% lower at d 3. Brachial FMD responses (6.9±3.6%) and plasma MDA, ARG, and ADMA concentrations were unaffected following LDL-C apheresis. A single LDL-C apheresis session did not alter FMD in patients treated chronically for hypercholesterolemia, a finding potentially attributed to the effect of chronic treatment or the decline in plasma antioxidants induced by cholesterol lowering. Funded by Kaneka Pharma, LLC" @default.
- W1565769935 created "2016-06-24" @default.
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- W1565769935 date "2015-04-01" @default.
- W1565769935 modified "2023-09-27" @default.
- W1565769935 title "Single LDL‐Cholesterol Apheresis Treatment Does Not Improve Vascular Endothelial Function in Hypercholesterolemic Patients" @default.
- W1565769935 doi "https://doi.org/10.1096/fasebj.29.1_supplement.643.1" @default.
- W1565769935 hasPublicationYear "2015" @default.
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