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• W1565853743 abstract "Abstract Early hematopoietic zinc finger/zinc finger protein 521 (EHZF/ZNF521) is a novel zinc finger protein expressed in hematopoietic stem and progenitor cells and is down-regulated during their differentiation. Its transcript is also abundant in some hematopoietic malignancies. Analysis of the changes in the antigenic profile of cells transfected with EHZF cDNA revealed up-regulation of HLA class I cell surface expression. This phenotypic change was associated with an increased level of HLA class I H chain, in absence of detectable changes in the expression of other Ag-processing machinery components. Enhanced resistance of target cells to NK cell-mediated cytotoxicity was induced by enforced expression of EHZF in the cervical carcinoma cell line HeLa and in the B lymphoblastoid cell line IM9. Preincubation of transfected cells with HLA class I Ag-specific mAb restored target cell susceptibility to NK cell-mediated lysis, indicating a specific role for HLA class I Ag up-regulation in the NK resistance induced by EHZF. A potential clinical significance of these findings is further suggested by the inverse correlation between EHZF and MHC class I expression levels, and autologous NK susceptibility of freshly explanted multiple myeloma cells." @default.
• W1565853743 created "2016-06-24" @default.
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• W1565853743 date "2009-04-15" @default.
• W1565853743 modified "2023-10-18" @default.
• W1565853743 title "Early Hematopoietic Zinc Finger Protein Prevents Tumor Cell Recognition by Natural Killer Cells" @default.
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• W1565853743 doi "https://doi.org/10.4049/jimmunol.0802109" @default.
• W1565853743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2747523" @default.
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