Matches in SemOpenAlex for { <https://semopenalex.org/work/W1565881570> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1565881570 endingPage "3" @default.
- W1565881570 startingPage "3320" @default.
- W1565881570 abstract "Hepatoblastoma is a rare hepatic malignancy that occurs in children with an average age of 2 or 3 years and is known to be one of the extracolonic manifestations of familial adenomatous polyposis. Only a single hepatoblastoma with a germ-line mutation of the adenomatous polyposis coli (APC) gene has been reported thus far. To elucidate the possible roles of APC gene alterations in sporadic hepatoblastomas, we examined loss of heterozygosity (LOH) at the APC and MCC loci and performed a sequencing analysis of a part of the APC gene, including the mutation cluster region, in 13 hepatoblastomas of non-familial adenomatous polyposis patients. LOH at the APC and/or MCC loci was observed in four of seven (57%) informative cases. Of the 13 cases, somatic mutations were detected in 8 (61.5%), with 9 (69%) cases showing genetic alterations in the APC gene as LOH or somatic mutations. Two cases demonstrated double mutations. Furthermore, the nature of the somatic mutations observed in the present study was unusual because 9 of the 10 mutations were missense, with only 1 case featuring a frame-shift mutation due to an insertion. Previous reports have described almost all (>90%) mutations of the APC gene in colorectal tumors to result in a truncated APC protein due to either frame-shift or nonsense mutations. These findings suggest that a mutation of the APC gene may play an important role in the genesis of sporadic hepatoblastomas, and the mechanisms of APC gene alteration may be different from those reported previously for colorectal tumors." @default.
- W1565881570 created "2016-06-24" @default.
- W1565881570 creator A5018720077 @default.
- W1565881570 creator A5023359954 @default.
- W1565881570 creator A5025109500 @default.
- W1565881570 creator A5056960216 @default.
- W1565881570 creator A5072022442 @default.
- W1565881570 date "1996-07-15" @default.
- W1565881570 modified "2023-10-03" @default.
- W1565881570 title "Somatic mutations of the APC gene in sporadic hepatoblastomas." @default.
- W1565881570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8764128" @default.
- W1565881570 hasPublicationYear "1996" @default.
- W1565881570 type Work @default.
- W1565881570 sameAs 1565881570 @default.
- W1565881570 citedByCount "43" @default.
- W1565881570 countsByYear W15658815702012 @default.
- W1565881570 countsByYear W15658815702014 @default.
- W1565881570 countsByYear W15658815702015 @default.
- W1565881570 countsByYear W15658815702016 @default.
- W1565881570 countsByYear W15658815702017 @default.
- W1565881570 countsByYear W15658815702018 @default.
- W1565881570 crossrefType "journal-article" @default.
- W1565881570 hasAuthorship W1565881570A5018720077 @default.
- W1565881570 hasAuthorship W1565881570A5023359954 @default.
- W1565881570 hasAuthorship W1565881570A5025109500 @default.
- W1565881570 hasAuthorship W1565881570A5056960216 @default.
- W1565881570 hasAuthorship W1565881570A5072022442 @default.
- W1565881570 hasConcept C104317684 @default.
- W1565881570 hasConcept C121608353 @default.
- W1565881570 hasConcept C126322002 @default.
- W1565881570 hasConcept C134305767 @default.
- W1565881570 hasConcept C13514818 @default.
- W1565881570 hasConcept C143589142 @default.
- W1565881570 hasConcept C180754005 @default.
- W1565881570 hasConcept C2776304256 @default.
- W1565881570 hasConcept C2778237340 @default.
- W1565881570 hasConcept C2780814781 @default.
- W1565881570 hasConcept C29906990 @default.
- W1565881570 hasConcept C2994225774 @default.
- W1565881570 hasConcept C501734568 @default.
- W1565881570 hasConcept C502942594 @default.
- W1565881570 hasConcept C526805850 @default.
- W1565881570 hasConcept C54355233 @default.
- W1565881570 hasConcept C71924100 @default.
- W1565881570 hasConcept C75563809 @default.
- W1565881570 hasConcept C86803240 @default.
- W1565881570 hasConcept C96777560 @default.
- W1565881570 hasConceptScore W1565881570C104317684 @default.
- W1565881570 hasConceptScore W1565881570C121608353 @default.
- W1565881570 hasConceptScore W1565881570C126322002 @default.
- W1565881570 hasConceptScore W1565881570C134305767 @default.
- W1565881570 hasConceptScore W1565881570C13514818 @default.
- W1565881570 hasConceptScore W1565881570C143589142 @default.
- W1565881570 hasConceptScore W1565881570C180754005 @default.
- W1565881570 hasConceptScore W1565881570C2776304256 @default.
- W1565881570 hasConceptScore W1565881570C2778237340 @default.
- W1565881570 hasConceptScore W1565881570C2780814781 @default.
- W1565881570 hasConceptScore W1565881570C29906990 @default.
- W1565881570 hasConceptScore W1565881570C2994225774 @default.
- W1565881570 hasConceptScore W1565881570C501734568 @default.
- W1565881570 hasConceptScore W1565881570C502942594 @default.
- W1565881570 hasConceptScore W1565881570C526805850 @default.
- W1565881570 hasConceptScore W1565881570C54355233 @default.
- W1565881570 hasConceptScore W1565881570C71924100 @default.
- W1565881570 hasConceptScore W1565881570C75563809 @default.
- W1565881570 hasConceptScore W1565881570C86803240 @default.
- W1565881570 hasConceptScore W1565881570C96777560 @default.
- W1565881570 hasIssue "14" @default.
- W1565881570 hasLocation W15658815701 @default.
- W1565881570 hasOpenAccess W1565881570 @default.
- W1565881570 hasPrimaryLocation W15658815701 @default.
- W1565881570 hasRelatedWork W1565881570 @default.
- W1565881570 hasRelatedWork W2027017149 @default.
- W1565881570 hasRelatedWork W2050754396 @default.
- W1565881570 hasRelatedWork W2064195641 @default.
- W1565881570 hasRelatedWork W2094547175 @default.
- W1565881570 hasRelatedWork W2106551200 @default.
- W1565881570 hasRelatedWork W2158044445 @default.
- W1565881570 hasRelatedWork W2171080110 @default.
- W1565881570 hasRelatedWork W2181034584 @default.
- W1565881570 hasRelatedWork W2946158458 @default.
- W1565881570 hasVolume "56" @default.
- W1565881570 isParatext "false" @default.
- W1565881570 isRetracted "false" @default.
- W1565881570 magId "1565881570" @default.
- W1565881570 workType "article" @default.