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- W1565931428 abstract "Infective dermatitis associated with human T lymphotropic cells virus type 1 (HTLV-1), IDH, is a form of severe and recurrent dermatitis that occurs mostly in children who were mainly vertically infected with HTLV-1, occurring erythematous, desquamative and crusty, being generally located in regions of the scalp and retroauricular, neck, groin, paranasal region, armpits, outer ear and nostrils. It begins after 18 months of life and rarely persists into adulthood. In Brazil, several cases have been diagnosed in Bahia, the Brazilian state that currently has the highest incidence after Jamaica. Tracking a cohort of 31 patients in the juvenile age group with IDH in Salvador, we observed the appearance of atypical lymphocytes (AL) and/or flower cells (FC), which are not commonly observed in patients with IDH, but occur frequently in patients with adult T cell leukemia/lymphoma (ATL), in peripheral blood smear in 11 of the subjects. Samples of 31 patients underwent tests of PCR assays to verify if there was a major clone by the clonality patterns of gamma-TCR. For this test, all 31 patients had oligoclonal pattern or typical polyclonal of IDH, where there isn’t a predominant clone. In order to verify if the appearance of the atypical cells was related to the future ATL we submitted the 11 subjects who had the AL and/or FC in peripheral blood smear to ILPCR tests conducted to analyze clonality of lymphocytes infected by the virus and subsequently these samples were sequenced to identify the integrations sites of the provirus in the host-carrier genome. A single dominant clone was observed in the PCR products from at least one of the tested samples in 7 of 11 individuals. In such cases, the proviral DNA did not interrupt coding regions for human gene. For a patient, the provirus was integrated in the region of the MAP2K1 gene (mitosis protein kinase activator 1), located on chromosome 15. We observed that in the presence of AL and/or FC may be majority clones circulating in HTLV- 1 carries with IDH." @default.
- W1565931428 created "2016-06-24" @default.
- W1565931428 creator A5027882243 @default.
- W1565931428 date "2014-01-01" @default.
- W1565931428 modified "2023-09-26" @default.
- W1565931428 title "Análise da integração viral e clonalidade de linfócitos T na dermatite infecciosa associada ao HTLV-1." @default.
- W1565931428 hasPublicationYear "2014" @default.
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