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- W1565959959 abstract "Hydrogenated amorphous silicon (a-Si:H) PIN photodiodes are used as fluorescence detectors for microfluidic biochemical and chemical analysis devices. A hybrid- integrated detector consisting of a half-ball lens, a ZnS/YF/sub 3/ multilayer optical interference filter with a pinhole, and an annular a-Si:H photodiode is developed that allows the laser excitation to pass up through the central aperture in the photodiode. Using this integrated device, the limit of detection for fluorescein flowing in a 50-/spl mu/m deep channel is 17 nM (S/N = 3). Furthermore, analysis of PCR amplicons generated from Staphylococcus aureus and chiral analysis of glutamic acid are successfully demonstrated. The a-Si:H detector exhibits high sensitivity at the emission wavelengths of commonly used fluorescent dyes and is readily microfabricated and integrated at low cost making it ideal for portable microfluidic bioanalyzers." @default.
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- W1565959959 date "2004-03-30" @default.
- W1565959959 modified "2023-09-27" @default.
- W1565959959 title "Microfluidic genetic and amino acid analysis using an integrated a-Si:H detector" @default.
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- W1565959959 doi "https://doi.org/10.1109/icsens.2003.1279103" @default.
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