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- W1565962783 abstract "Purpose: The failing heart is characterized by alterations in energy metabolism. To screen for cell-surface proteins showing enhanced expression under metabolic stress, we performed a signal sequence trap in combination with a functional cloning method. Methods and results: We screened for cell-surface proteins showing enhanced expression using oligomycin, a mitochondorial inhibitor in H9C2 rat cardiac myoblasts. One of the identified genes was neural cell adhesion molecule (NCAM). In H9C2 and primary rat cardiac myocytes, oligomycin treatment significantly upregulated the mRNA and protein level of NCAM in a p38-dependent manner, whereas phenylephrine and AT-II did not. To analyze the expression pattern of NCAM in diseased hearts in vivo, we examined the NCAM expression in a mouse MI model. mRNA was upregulated 15.2±0.20 fold in the infarcted area (P Conclusion: NCAM may play a protective role in the metabolically stressed heart and may be available as a new therapeutic target." @default.
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- W1565962783 date "2009-11-03" @default.
- W1565962783 modified "2023-09-23" @default.
- W1565962783 title "Abstract 1912: Neural Cell Adhesion Molecule is a Cardioprotective Factor Upregulated by Metabolic Stress" @default.
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