FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1565987005> ?p ?o ?g. }

• W1565987005 endingPage "14" @default.
• W1565987005 startingPage "702" @default.
• W1565987005 abstract "Leukemia cell infiltration and the induction of lethal hematopoietic disease in immune-deficient SCID mice transplanted with human T cell acute lymphoblastic T leukemia (T-ALL) cells occurred only when the cells possessed mutant p53 genes and lacked a wild-type allele or when T-ALL cells lacking p53 protein were infected with specific mutant p53 genes. A series of six mutant p53 genes were cloned from relapse T-ALL-derived cell lines and were constructed into defective retroviral expression vectors. Viruses encoding mutant p53 proteins were used to infect relapse T-ALL cells in a study designed to compare their pathogenic potency. The mutant p53 genes possessed a distinct hierarchy in vivo and in vitro: mutants inducing the greatest increase in proliferation of different T-ALL lines in vitro and colony formation in methylcellulose cultures also induced tissue invasiveness of infected T-ALL cells in vivo. Mutant p53 gene transfer to a cell line lacking p53 protein showed that the more potent p53 mutants possessed a distinctive dominant oncogenic activity in vitro and in vivo. The dominant oncogenic activity of these mutant p53 proteins was not dependent on the presence of and on complex formation with wild-type p53 protein. These hot p53 mutations thus represent bona fide gain-of-function mutations. Infection of p53-negative T-ALL cells with viruses encoding gain-of-function mutant p53 genes resulted in the acquisition of metastatic potential and tissue invasiveness. Taken together, our results suggest that specific mutant p53 genes play a role in the generation of lymphohematopoietic metastatic potential and tissue invasiveness as assayed in SCID mice, whereas the expression of wild-type p53 is capable of keeping this metastatic potential in check." @default.
• W1565987005 created "2016-06-24" @default.
• W1565987005 creator A5007350954 @default.
• W1565987005 creator A5029264085 @default.
• W1565987005 creator A5032519338 @default.
• W1565987005 creator A5040963005 @default.
• W1565987005 creator A5046865347 @default.
• W1565987005 creator A5060183326 @default.
• W1565987005 creator A5076048262 @default.
• W1565987005 date "1994-09-01" @default.
• W1565987005 modified "2023-09-24" @default.
• W1565987005 title "Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness." @default.
• W1565987005 cites W1550454523 @default.
• W1565987005 cites W1554072136 @default.
• W1565987005 cites W1564956131 @default.
• W1565987005 cites W156574667 @default.
• W1565987005 cites W1579659806 @default.
• W1565987005 cites W1612798868 @default.
• W1565987005 cites W1645741024 @default.
• W1565987005 cites W174785446 @default.
• W1565987005 cites W1768423394 @default.
• W1565987005 cites W1822460389 @default.
• W1565987005 cites W1831734000 @default.
• W1565987005 cites W186474185 @default.
• W1565987005 cites W1903324674 @default.
• W1565987005 cites W1935791347 @default.
• W1565987005 cites W1946599180 @default.
• W1565987005 cites W1947531295 @default.
• W1565987005 cites W1952751041 @default.
• W1565987005 cites W1954929088 @default.
• W1565987005 cites W1972741795 @default.
• W1565987005 cites W1976971420 @default.
• W1565987005 cites W1980066350 @default.
• W1565987005 cites W1982259691 @default.
• W1565987005 cites W1989887575 @default.
• W1565987005 cites W1995095999 @default.
• W1565987005 cites W1998543370 @default.
• W1565987005 cites W2003236156 @default.
• W1565987005 cites W2004144304 @default.
• W1565987005 cites W2006416369 @default.
• W1565987005 cites W2008630922 @default.
• W1565987005 cites W2013136213 @default.
• W1565987005 cites W2013461463 @default.
• W1565987005 cites W2015274522 @default.
• W1565987005 cites W2017293277 @default.
• W1565987005 cites W2027157544 @default.
• W1565987005 cites W2037722096 @default.
• W1565987005 cites W2042316019 @default.
• W1565987005 cites W2043912950 @default.
• W1565987005 cites W2048375085 @default.
• W1565987005 cites W2053504819 @default.
• W1565987005 cites W2057805027 @default.
• W1565987005 cites W2060490849 @default.
• W1565987005 cites W2063158632 @default.
• W1565987005 cites W2063380435 @default.
• W1565987005 cites W2068691401 @default.
• W1565987005 cites W2074114480 @default.
• W1565987005 cites W2076059928 @default.
• W1565987005 cites W2081948388 @default.
• W1565987005 cites W2085295693 @default.
• W1565987005 cites W2091987058 @default.
• W1565987005 cites W2097752832 @default.
• W1565987005 cites W2097794242 @default.
• W1565987005 cites W2099907467 @default.
• W1565987005 cites W2102826458 @default.
• W1565987005 cites W2113535517 @default.
• W1565987005 cites W2117971688 @default.
• W1565987005 cites W2126679757 @default.
• W1565987005 cites W2127952872 @default.
• W1565987005 cites W2128060680 @default.
• W1565987005 cites W2134858249 @default.
• W1565987005 cites W2138526425 @default.
• W1565987005 cites W2150097377 @default.
• W1565987005 cites W2163565167 @default.
• W1565987005 cites W2164697719 @default.
• W1565987005 cites W2167759582 @default.
• W1565987005 cites W2169441459 @default.
• W1565987005 cites W2171672241 @default.
• W1565987005 cites W2178538878 @default.
• W1565987005 cites W2255191999 @default.
• W1565987005 cites W2258528303 @default.
• W1565987005 cites W2398619533 @default.
• W1565987005 cites W2413370256 @default.
• W1565987005 cites W2419596057 @default.
• W1565987005 cites W2468717450 @default.
• W1565987005 cites W2472494377 @default.
• W1565987005 cites W2473890412 @default.
• W1565987005 cites W73095912 @default.
• W1565987005 cites W1941685106 @default.
• W1565987005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1890319" @default.
• W1565987005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8080050" @default.
• W1565987005 hasPublicationYear "1994" @default.
• W1565987005 type Work @default.
• W1565987005 sameAs 1565987005 @default.
• W1565987005 citedByCount "60" @default.
• W1565987005 countsByYear W15659870052012 @default.
• W1565987005 countsByYear W15659870052014 @default.
• W1565987005 countsByYear W15659870052015 @default.

• next