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- W1566007850 abstract "Deoxynucleosides have demonstrated prominent antiviral and antitumoral activities, [1] leading to the development of several drugs, including but not limited to zidovudine, stavudine, trifluridine, idoxuridine, cladribine and didanosine (Fig. 1). Extraction from natural sources and fermentation processes can only provide a limited number of naturally-occurring 2’-deoxynucleosides; therefore, synthetic approaches to the preparation of deoxynucleosides are highly desired. [2] The most common approach involves the direct SN2 reaction of metal salts or silylated nitrogenous bases with 1-chloro-2-deoxyribose derivatives (Scheme 1, Approach A). However, 1-chloro sugars are expensive and unstable, and the substitution reaction often generates a mixture of anomers that are difficult to separate. [2a] Another method involves the radical deoxygenation reaction of ribonucleosides when the C2’hydroxyl group is derivatized as a phenoxythiocarbonyl ester. [3] Nevertheless, this method is hampered by the use of a stoichiometric amount of toxic reagent n Bu3SnH, and is only applicable to naturally-occurring ribonucleosides." @default.
- W1566007850 created "2016-06-24" @default.
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- W1566007850 date "2013-11-01" @default.
- W1566007850 modified "2023-09-24" @default.
- W1566007850 title "Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides" @default.
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