Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566044237> ?p ?o ?g. }
- W1566044237 endingPage "197" @default.
- W1566044237 startingPage "185" @default.
- W1566044237 abstract "The aim of this research was to estimate the efficacy and safety of current high-density lipoprotein cholesterol (HDL-C)-increasing drugs.Epidemiologic evidence has shown that HDL-C is inversely related to coronary heart disease (CHD) risk. However, the evidence for reducing CHD risk by raising HDL-C is thin, predominantly due to the paucity of effective and safe HDL-increasing drugs.Randomized controlled trials with fibrates and niacin, published between 1966 through February 2004 (MEDLINE), were retrieved. Information on treatment, baseline characteristics, serum lipids, end points, and side-effects were independently abstracted by two authors using a standardized protocol.Data from 53 trials (16,802 subjects) using fibrates and 30 trials (4,749 subjects) using niacin were included. Random-effects model showed 11% versus 10% reduction in total cholesterol, 36% versus 20% reduction in triglycerides, 8% versus 14% reduction in low-density lipoprotein cholesterol, and 10% versus 16% increase in HDL-C for fibrates and niacin, respectively. Apart from flushes in the niacin group, both fibrates and niacin were shown to be well-tolerated and safe. Fibrates reduced the risk for major coronary events by 25% (95% confidence interval 10% to 38%), whereas current available data for niacin indicate a 27% reduction.Fibrates reduce major coronary events and increase HDL-C levels without significant toxicity. Niacin has a more potent effect on HDL-C levels, whereas data on cardiovascular event rate reduction are limited. Future studies need to evaluate whether additional HDL increase by fibrates or particularly newer niacin formulations on top of statin therapy translates into further event reduction in high-risk subjects, without significant toxicity." @default.
- W1566044237 created "2016-06-24" @default.
- W1566044237 creator A5015459043 @default.
- W1566044237 creator A5064131836 @default.
- W1566044237 creator A5077848934 @default.
- W1566044237 creator A5081557648 @default.
- W1566044237 date "2005-01-01" @default.
- W1566044237 modified "2023-10-14" @default.
- W1566044237 title "Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds" @default.
- W1566044237 cites W1491336995 @default.
- W1566044237 cites W1502524639 @default.
- W1566044237 cites W1509914447 @default.
- W1566044237 cites W1529036441 @default.
- W1566044237 cites W1964471496 @default.
- W1566044237 cites W1966387439 @default.
- W1566044237 cites W1967150290 @default.
- W1566044237 cites W1969723476 @default.
- W1566044237 cites W1971175832 @default.
- W1566044237 cites W1971185347 @default.
- W1566044237 cites W1972295561 @default.
- W1566044237 cites W1980636050 @default.
- W1566044237 cites W1981670728 @default.
- W1566044237 cites W1985798759 @default.
- W1566044237 cites W1986416204 @default.
- W1566044237 cites W1990547751 @default.
- W1566044237 cites W1993344180 @default.
- W1566044237 cites W1994387199 @default.
- W1566044237 cites W1998704804 @default.
- W1566044237 cites W2000921060 @default.
- W1566044237 cites W2003636496 @default.
- W1566044237 cites W2003992056 @default.
- W1566044237 cites W2005447634 @default.
- W1566044237 cites W2005761359 @default.
- W1566044237 cites W2005870798 @default.
- W1566044237 cites W2007419791 @default.
- W1566044237 cites W2011412478 @default.
- W1566044237 cites W2012633407 @default.
- W1566044237 cites W2014894063 @default.
- W1566044237 cites W2015868521 @default.
- W1566044237 cites W2019863077 @default.
- W1566044237 cites W2021515095 @default.
- W1566044237 cites W2021863348 @default.
- W1566044237 cites W2023732057 @default.
- W1566044237 cites W2026792133 @default.
- W1566044237 cites W2027679949 @default.
- W1566044237 cites W2028211844 @default.
- W1566044237 cites W2028347835 @default.
- W1566044237 cites W2033451677 @default.
- W1566044237 cites W2034600674 @default.
- W1566044237 cites W2037328752 @default.
- W1566044237 cites W2038510613 @default.
- W1566044237 cites W2038561302 @default.
- W1566044237 cites W2040073338 @default.
- W1566044237 cites W2041768527 @default.
- W1566044237 cites W2043180355 @default.
- W1566044237 cites W2046991199 @default.
- W1566044237 cites W2050833909 @default.
- W1566044237 cites W2053319196 @default.
- W1566044237 cites W2055318521 @default.
- W1566044237 cites W2057065030 @default.
- W1566044237 cites W2060564120 @default.
- W1566044237 cites W2061856535 @default.
- W1566044237 cites W2068768742 @default.
- W1566044237 cites W2070999659 @default.
- W1566044237 cites W2072734670 @default.
- W1566044237 cites W2078362634 @default.
- W1566044237 cites W2082264235 @default.
- W1566044237 cites W2086896699 @default.
- W1566044237 cites W2087873993 @default.
- W1566044237 cites W2089016920 @default.
- W1566044237 cites W2092065608 @default.
- W1566044237 cites W2093355041 @default.
- W1566044237 cites W2095507444 @default.
- W1566044237 cites W2100447241 @default.
- W1566044237 cites W2104226967 @default.
- W1566044237 cites W2104371146 @default.
- W1566044237 cites W2107328434 @default.
- W1566044237 cites W2108834780 @default.
- W1566044237 cites W2112786561 @default.
- W1566044237 cites W2117092539 @default.
- W1566044237 cites W2117179212 @default.
- W1566044237 cites W2119065130 @default.
- W1566044237 cites W2125692663 @default.
- W1566044237 cites W2131620609 @default.
- W1566044237 cites W2142310756 @default.
- W1566044237 cites W2145034104 @default.
- W1566044237 cites W2145970366 @default.
- W1566044237 cites W2147098206 @default.
- W1566044237 cites W2148302971 @default.
- W1566044237 cites W2150968881 @default.
- W1566044237 cites W2152195987 @default.
- W1566044237 cites W2156734315 @default.
- W1566044237 cites W2160689800 @default.
- W1566044237 cites W2166910397 @default.
- W1566044237 cites W2168231835 @default.
- W1566044237 cites W2169911638 @default.
- W1566044237 cites W2170791595 @default.
- W1566044237 cites W2171667331 @default.