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• W1566065433 abstract "Sclerocarya birrea fruits are widely eaten in developing countries especially in rural areas where they serve as nutritional supplements. However, they may also contain phyto-toxins which may affect the normal functioning of the body. Acute toxicity study was performed by a single oral administration of a dose of 3000 mg/kg body weight. Sub chronic toxicity evaluation was conducted by oral feeding of the rats with the peels extract daily at doses of 1000, 2000, 3000 and 4000 mg/kg body weight for 28 days. The results of acute toxicity show no mortality and general behaviour changes. The lethal dosage (LD 50 ) was greater than 3000 mg/kg body weight. Rats fed with 1000, 2000 and 3000mg/kg body weight of the extract have higher body weights throughout the period of treatment but not significantly (p>0.05) different from the control group. Rats fed with 4000mg/kg body weight have significantly (p<0.05) lower body weight throughout the period of treatment. Significantly (p<0.05) higher serum total proteins, albumin, bilirubin, transaminases, creatinine, urea, uric acid and electrolytes were recorded in rats fed with 3000 to 4000 mg/kg body weight of the extract, suggesting liver and kidney toxicities. Therefore, the peels extract of S. birrea may be relatively toxic at doses of 3000 and 4000 mg/kg body weight. Further studies are required for isolation and characterization of the toxic compounds." @default.
• W1566065433 created "2016-06-24" @default.
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• W1566065433 date "2014-01-24" @default.
• W1566065433 modified "2023-09-27" @default.
• W1566065433 title "Acute and Subchronic Toxicity Studies of Sclerocarya birrea Peels Extract in Rats" @default.
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