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- W156611128 abstract "Copper-62 labeled pyruvaldehyde bis(N4-methylthiosemicarbazone) (Cu-62 PTSM) has been proposed as a generator-produced positron emitting tracer for perfusion imaging with PET. In order to evaluate the characteristics of Cu-62 PTSM as a cerebral perfusion tracer, brain PET imaging of Cu-62 PTSM and regional cerebral blood flow (rCBF) measurement with O-15 labeled water were performed in 10 subjects. Following rCBF measurement using intravenous injection of O-15 water and autoradiographic method, dynamic PET data were obtained for 10 minutes after intravenous injection of 10-20 mCi of Cu-62 PTSM with arterial sampling. Serial PET images and octanol-extracted arterial input function suggested significant back-diffusion of Cu-62 PTSM from the brain shortly after injection, followed by stable activity for 10 minutes. The final retention fraction estimated by rCBF as a reference was 0.45{plus_minus}0.10. Comparison with rCBF images obtained by O-15 water PET demonstrated a non-linear relationship of flow and Cu-62 PTSM uptake, suggesting the underestimation of flow in the high flow regions due to back-diffusion. After the correction of Cu-62 PTSM image with arterial input function and individual retention fraction, Cu-PTSM showed an excellent correlation with rCBF. In conclusion, although Cu-62 PTSM can be used widely for imaging relative rCBF distribution, the kinetic analysis and correctionmore » would be necessary to quantify rCBF.« less" @default.
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- W156611128 title "Quantitative evaluation of generator-produced copper-62 PTSM as a brain perfusion tracer for PET" @default.
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