FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W156611541> ?p ?o ?g. }

• W156611541 endingPage "83" @default.
• W156611541 startingPage "65" @default.
• W156611541 abstract "Interleukin-12 (IL-12) was identified independently by two groups. The first group, at Hoffmann-La Roche, was studying a cytokine, named cytotoxic lymphocyte maturation factor (CLMF), that activated cytolytic lymphocyte activities (Stern et al. 1990). The second group, at the Wistar Institute, was evaluating a cytokine, originally named natural killer (NK) cell stimulatory factor (NKSF), that could stimulate NK cell functions (Kobayashi et al. 1989). Once CLMF and NKSF were characterized and cloned, it became clear that this was in fact one molecule, which is now called IL-12. IL-12 has profound effects on both NK and T cells, including the ability to stimulate proliferation, cytolytic activity, and cytokine induction. Furthermore, it plays a major role in regulating the induction of T cell subsets and thus is an important component of the immune response to foreign antigens. Based on these properties, IL-12 was evaluated in animal models of malignancies and shown to have potent antitumor and antimetastatic activities. In this chapter, we will summarize some of the biological effects of IL-12 and show how these relate to the in vivo effects of this cytokine on malignancies. Additional information on IL-12 can be found in a number of review articles (Brunda 1994; Gately et al. 1994a; Brunda and Gately 1994; Trinchieri 1994; Gately and Brunda 1995; Brunda and Gately 1995; Hendrzak and Brunda 1995)." @default.
• W156611541 created "2016-06-24" @default.
• W156611541 creator A5039567773 @default.
• W156611541 creator A5065670722 @default.
• W156611541 date "1996-01-01" @default.
• W156611541 modified "2023-09-26" @default.
• W156611541 title "Antitumor and Antimetastatic Activity of lnterleukin-12" @default.
• W156611541 cites W1492544523 @default.
• W156611541 cites W1495915055 @default.
• W156611541 cites W1499249521 @default.
• W156611541 cites W1501256648 @default.
• W156611541 cites W1502343210 @default.
• W156611541 cites W1515175043 @default.
• W156611541 cites W1517394132 @default.
• W156611541 cites W1524541469 @default.
• W156611541 cites W1536478289 @default.
• W156611541 cites W1546278502 @default.
• W156611541 cites W1546288178 @default.
• W156611541 cites W1549867593 @default.
• W156611541 cites W1561485846 @default.
• W156611541 cites W1562140960 @default.
• W156611541 cites W1566680641 @default.
• W156611541 cites W1573438651 @default.
• W156611541 cites W1605448181 @default.
• W156611541 cites W1610828262 @default.
• W156611541 cites W1631611187 @default.
• W156611541 cites W1644502582 @default.
• W156611541 cites W1656968650 @default.
• W156611541 cites W1793546710 @default.
• W156611541 cites W1829938205 @default.
• W156611541 cites W1838853754 @default.
• W156611541 cites W1924633993 @default.
• W156611541 cites W1940408935 @default.
• W156611541 cites W1945740511 @default.
• W156611541 cites W1948447751 @default.
• W156611541 cites W1963664915 @default.
• W156611541 cites W1964323924 @default.
• W156611541 cites W1970847065 @default.
• W156611541 cites W1977355512 @default.
• W156611541 cites W1977817262 @default.
• W156611541 cites W1979514172 @default.
• W156611541 cites W1981148628 @default.
• W156611541 cites W1982798395 @default.
• W156611541 cites W1985456177 @default.
• W156611541 cites W1988672382 @default.
• W156611541 cites W1991005417 @default.
• W156611541 cites W1994303699 @default.
• W156611541 cites W1995700626 @default.
• W156611541 cites W2002505245 @default.
• W156611541 cites W2005182655 @default.
• W156611541 cites W2005945501 @default.
• W156611541 cites W2006073656 @default.
• W156611541 cites W2006178861 @default.
• W156611541 cites W2012440544 @default.
• W156611541 cites W2014582730 @default.
• W156611541 cites W2027874358 @default.
• W156611541 cites W2028500185 @default.
• W156611541 cites W2028688116 @default.
• W156611541 cites W2032980904 @default.
• W156611541 cites W2036472878 @default.
• W156611541 cites W2038260086 @default.
• W156611541 cites W2042106455 @default.
• W156611541 cites W2046399828 @default.
• W156611541 cites W2048051635 @default.
• W156611541 cites W2049653889 @default.
• W156611541 cites W2051904905 @default.
• W156611541 cites W2054589217 @default.
• W156611541 cites W2056859114 @default.
• W156611541 cites W2058995661 @default.
• W156611541 cites W2066930845 @default.
• W156611541 cites W2067877107 @default.
• W156611541 cites W2069173092 @default.
• W156611541 cites W2070762522 @default.
• W156611541 cites W2072128323 @default.
• W156611541 cites W2077465724 @default.
• W156611541 cites W2082335444 @default.
• W156611541 cites W2083148270 @default.
• W156611541 cites W2088953386 @default.
• W156611541 cites W2091217693 @default.
• W156611541 cites W2095370288 @default.
• W156611541 cites W2095835949 @default.
• W156611541 cites W2101956767 @default.
• W156611541 cites W2102156468 @default.
• W156611541 cites W2103033656 @default.
• W156611541 cites W2104439753 @default.
• W156611541 cites W2105440061 @default.
• W156611541 cites W2106678929 @default.
• W156611541 cites W2110420859 @default.
• W156611541 cites W2114131840 @default.
• W156611541 cites W2115954882 @default.
• W156611541 cites W2116641130 @default.
• W156611541 cites W2117173150 @default.
• W156611541 cites W2119969523 @default.
• W156611541 cites W2121364429 @default.
• W156611541 cites W2126043069 @default.
• W156611541 cites W2128390153 @default.
• W156611541 cites W2134927627 @default.
• W156611541 cites W2135041525 @default.

• next