FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566138257> ?p ?o ?g. }

• W1566138257 abstract "To explore the effect of immunization with copolymer-1 (COP-1) and retinal stem cells (RSCs) transplantation on interferon-gamma (IFN-γ) levels in a rat experimental glaucoma model.An experimental glaucoma was induced by argon laser photocoagulation of the episcleral veins and limbal plexus in the right eye of rats. Immediately following glaucoma induction, rats were immunized with COP-1. RSCs were cultured and transplanted intravitreally into the eyes of glaucoma model animals 1 week post-laser treatment. Six experimental groups were used: COP-1/RSC, PBS/RSC, COP-1/PBS, PBS/PBS, glaucoma model group, and a normal control group. The concentration of IFN-γ in aqueous humor (AH) and serum was measured by enzyme-linked immunosorbent assay (ELISA) in each of the six groups. Retinal ganglion cell (RGC) survival was assessed by quantifying apoptosis using Hoechst staining.Concentrations of IFN-γ in AH and serum of rats that had undergone glaucoma induction were higher than those of non-induced control rats. The concentrations of IFN-γ in AH and serum of the COP-1/RSCs treated group were determined to be 2371.9ng/L and 710.9ng/L, respectively, which were significantly lower than those in the other treated groups (P<0.05). In fact, IFN-γ levels in the dual treated group were reduced to background levels. The COP-1/RSC group had lower number of apoptotic RGCs than the other three experimental groups (P<0.05).The reduced levels of IFN-γ in AH and serum of the COP-1/RSC group may be related to synergistic effects between RSCs transplantation and COP-1 immune modulation. It is likely that the lower levels of IFN-γ prevented RGCs glaucomatous apoptosis." @default.
• W1566138257 created "2016-06-24" @default.
• W1566138257 creator A5068087395 @default.
• W1566138257 creator A5073698983 @default.
• W1566138257 date "2011-01-01" @default.
• W1566138257 modified "2023-09-23" @default.
• W1566138257 title "Retinal stem cells transplantation combined with copolymer-1 immunization reduces interferon-gamma levels in an experimental model of glaucoma." @default.
• W1566138257 cites W1500206592 @default.
• W1566138257 cites W1544105159 @default.
• W1566138257 cites W1624269173 @default.
• W1566138257 cites W1862999254 @default.
• W1566138257 cites W1969772753 @default.
• W1566138257 cites W1982010119 @default.
• W1566138257 cites W1982606894 @default.
• W1566138257 cites W1998871738 @default.
• W1566138257 cites W2014091945 @default.
• W1566138257 cites W2026492930 @default.
• W1566138257 cites W2034637876 @default.
• W1566138257 cites W2049041989 @default.
• W1566138257 cites W2051992221 @default.
• W1566138257 cites W2061217789 @default.
• W1566138257 cites W2063986567 @default.
• W1566138257 cites W2089583567 @default.
• W1566138257 cites W2090137827 @default.
• W1566138257 cites W2106287544 @default.
• W1566138257 cites W2113155599 @default.
• W1566138257 cites W2114268866 @default.
• W1566138257 cites W2120304599 @default.
• W1566138257 cites W2141057018 @default.
• W1566138257 cites W2145533845 @default.
• W1566138257 cites W2169104281 @default.
• W1566138257 cites W2170899083 @default.
• W1566138257 cites W2615076472 @default.
• W1566138257 doi "https://doi.org/10.3980/j.issn.2222-3959.2011.06.04" @default.
• W1566138257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3340800" @default.
• W1566138257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22553727" @default.
• W1566138257 hasPublicationYear "2011" @default.
• W1566138257 type Work @default.
• W1566138257 sameAs 1566138257 @default.
• W1566138257 citedByCount "4" @default.
• W1566138257 countsByYear W15661382572015 @default.
• W1566138257 countsByYear W15661382572017 @default.
• W1566138257 countsByYear W15661382572019 @default.
• W1566138257 countsByYear W15661382572021 @default.
• W1566138257 crossrefType "journal-article" @default.
• W1566138257 hasAuthorship W1566138257A5068087395 @default.
• W1566138257 hasAuthorship W1566138257A5073698983 @default.
• W1566138257 hasConcept C118487528 @default.
• W1566138257 hasConcept C141071460 @default.
• W1566138257 hasConcept C203014093 @default.
• W1566138257 hasConcept C2778527774 @default.
• W1566138257 hasConcept C2780801004 @default.
• W1566138257 hasConcept C2780827179 @default.
• W1566138257 hasConcept C2911091166 @default.
• W1566138257 hasConcept C71924100 @default.
• W1566138257 hasConcept C8891405 @default.
• W1566138257 hasConceptScore W1566138257C118487528 @default.
• W1566138257 hasConceptScore W1566138257C141071460 @default.
• W1566138257 hasConceptScore W1566138257C203014093 @default.
• W1566138257 hasConceptScore W1566138257C2778527774 @default.
• W1566138257 hasConceptScore W1566138257C2780801004 @default.
• W1566138257 hasConceptScore W1566138257C2780827179 @default.
• W1566138257 hasConceptScore W1566138257C2911091166 @default.
• W1566138257 hasConceptScore W1566138257C71924100 @default.
• W1566138257 hasConceptScore W1566138257C8891405 @default.
• W1566138257 hasLocation W15661382571 @default.
• W1566138257 hasOpenAccess W1566138257 @default.
• W1566138257 hasPrimaryLocation W15661382571 @default.
• W1566138257 hasRelatedWork W2019815579 @default.
• W1566138257 hasRelatedWork W2053115051 @default.
• W1566138257 hasRelatedWork W2070021475 @default.
• W1566138257 hasRelatedWork W2166781715 @default.
• W1566138257 hasRelatedWork W2316119374 @default.
• W1566138257 hasRelatedWork W2477981923 @default.
• W1566138257 hasRelatedWork W376898147 @default.
• W1566138257 isParatext "false" @default.
• W1566138257 isRetracted "false" @default.
• W1566138257 magId "1566138257" @default.
• W1566138257 workType "article" @default.