FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566149938> ?p ?o ?g. }

• W1566149938 endingPage "2125" @default.
• W1566149938 startingPage "2118" @default.
• W1566149938 abstract "To investigate the in vivo function of Fas ligand (FasL), we produced a mouse strain with a FasL gene flanked by loxP sequences. Mice with homozygous floxed FasL gene showed no obvious abnormalities. However, germline deletion of the FasL gene, obtained after mating with mice expressing ubiquitous Cre recombinase, resulted in an unexpectedly severe phenotype. FasL(-/-) mice exhibited an extreme splenomegaly and lymphadenopathy associated with lymphocytic infiltration into multiple organs and autoimmune disease. This severe phenotype led to the premature death at 4 mo of age of >50% of the homozygous mice. It stands in sharp contrast with the milder disease observed in gld (generalized lymphoproliferative disease) mice, indicating that the FasL allele of these mice encodes a protein still able to bind, albeit at a very low level, the Fas receptor." @default.
• W1566149938 created "2016-06-24" @default.
• W1566149938 creator A5008403529 @default.
• W1566149938 creator A5016142788 @default.
• W1566149938 creator A5018238719 @default.
• W1566149938 creator A5032288631 @default.
• W1566149938 creator A5075646456 @default.
• W1566149938 creator A5086859296 @default.
• W1566149938 creator A5090574025 @default.
• W1566149938 date "2004-02-15" @default.
• W1566149938 modified "2023-10-11" @default.
• W1566149938 title "Complete Loss of <i>Fas Ligand</i> Gene Causes Massive Lymphoproliferation and Early Death, Indicating a Residual Activity of <i>gld</i> Allele" @default.
• W1566149938 cites W1505372769 @default.
• W1566149938 cites W1597224120 @default.
• W1566149938 cites W1638118783 @default.
• W1566149938 cites W1653284008 @default.
• W1566149938 cites W1978018492 @default.
• W1566149938 cites W1978428745 @default.
• W1566149938 cites W1980995033 @default.
• W1566149938 cites W2000820719 @default.
• W1566149938 cites W2012209476 @default.
• W1566149938 cites W2016198585 @default.
• W1566149938 cites W2026284067 @default.
• W1566149938 cites W2027012549 @default.
• W1566149938 cites W2036109455 @default.
• W1566149938 cites W2037804577 @default.
• W1566149938 cites W2039642400 @default.
• W1566149938 cites W2041466047 @default.
• W1566149938 cites W2045068005 @default.
• W1566149938 cites W2046533194 @default.
• W1566149938 cites W2058823301 @default.
• W1566149938 cites W2065413461 @default.
• W1566149938 cites W2076229621 @default.
• W1566149938 cites W2078901980 @default.
• W1566149938 cites W2085173450 @default.
• W1566149938 cites W2085583663 @default.
• W1566149938 cites W2086322467 @default.
• W1566149938 cites W2087339935 @default.
• W1566149938 cites W2091490997 @default.
• W1566149938 cites W2106393985 @default.
• W1566149938 cites W2106655707 @default.
• W1566149938 cites W2126715968 @default.
• W1566149938 cites W2145320056 @default.
• W1566149938 cites W2151365647 @default.
• W1566149938 cites W2154757961 @default.
• W1566149938 cites W2179862924 @default.
• W1566149938 doi "https://doi.org/10.4049/jimmunol.172.4.2118" @default.
• W1566149938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14764677" @default.
• W1566149938 hasPublicationYear "2004" @default.
• W1566149938 type Work @default.
• W1566149938 sameAs 1566149938 @default.
• W1566149938 citedByCount "74" @default.
• W1566149938 countsByYear W15661499382012 @default.
• W1566149938 countsByYear W15661499382013 @default.
• W1566149938 countsByYear W15661499382014 @default.
• W1566149938 countsByYear W15661499382015 @default.
• W1566149938 countsByYear W15661499382016 @default.
• W1566149938 countsByYear W15661499382017 @default.
• W1566149938 countsByYear W15661499382018 @default.
• W1566149938 countsByYear W15661499382019 @default.
• W1566149938 countsByYear W15661499382020 @default.
• W1566149938 countsByYear W15661499382022 @default.
• W1566149938 countsByYear W15661499382023 @default.
• W1566149938 crossrefType "journal-article" @default.
• W1566149938 hasAuthorship W1566149938A5008403529 @default.
• W1566149938 hasAuthorship W1566149938A5016142788 @default.
• W1566149938 hasAuthorship W1566149938A5018238719 @default.
• W1566149938 hasAuthorship W1566149938A5032288631 @default.
• W1566149938 hasAuthorship W1566149938A5075646456 @default.
• W1566149938 hasAuthorship W1566149938A5086859296 @default.
• W1566149938 hasAuthorship W1566149938A5090574025 @default.
• W1566149938 hasBestOaLocation W15661499381 @default.
• W1566149938 hasConcept C102230213 @default.
• W1566149938 hasConcept C104317684 @default.
• W1566149938 hasConcept C109825262 @default.
• W1566149938 hasConcept C125929170 @default.
• W1566149938 hasConcept C127716648 @default.
• W1566149938 hasConcept C141035611 @default.
• W1566149938 hasConcept C153911025 @default.
• W1566149938 hasConcept C180754005 @default.
• W1566149938 hasConcept C190283241 @default.
• W1566149938 hasConcept C203014093 @default.
• W1566149938 hasConcept C3031857 @default.
• W1566149938 hasConcept C31573885 @default.
• W1566149938 hasConcept C54355233 @default.
• W1566149938 hasConcept C66008609 @default.
• W1566149938 hasConcept C86803240 @default.
• W1566149938 hasConceptScore W1566149938C102230213 @default.
• W1566149938 hasConceptScore W1566149938C104317684 @default.
• W1566149938 hasConceptScore W1566149938C109825262 @default.
• W1566149938 hasConceptScore W1566149938C125929170 @default.
• W1566149938 hasConceptScore W1566149938C127716648 @default.
• W1566149938 hasConceptScore W1566149938C141035611 @default.
• W1566149938 hasConceptScore W1566149938C153911025 @default.
• W1566149938 hasConceptScore W1566149938C180754005 @default.
• W1566149938 hasConceptScore W1566149938C190283241 @default.
• W1566149938 hasConceptScore W1566149938C203014093 @default.
• W1566149938 hasConceptScore W1566149938C3031857 @default.

• next