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- W156615204 abstract "Tetrahydrobiopterin (BH4) is the natural cofactor of Phenylalanine, tyrosine and tryptophan hydroxylases as well as nitric oxide synthase1-5. BH4 is synthesized from GTP by successive actions of at least three enzymes2,6, namely, GTP cyclohydrolase I, 6-pyruvoyltetrahydropterin synthase (PTPS) and sepiapterin reductase (SR)2,6. BH4 is regenerated by dihydropteridine reductase (DHPR) from quinonoid dihydrobiopterin2. The activities of these BH4-generating enzymes have been measured in various tissues7–10, but the expression of their genes has not been fully elucidated. Herein, we examined the transcriptional regulation of BH4-generating enzymes in various tissues. Northern blot analysis was performed with cDNA probes of these enzymes to determine the mRNA levels of the BH4-generating enzymes. Our purposes are: to examine the spatial spectra of the mRNA of the BH4-generating enzymes and compare them with their enzyme activities; 2) to determine whether the mRNA expression of these enzymes differ with the tissue." @default.
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- W156615204 date "1993-01-01" @default.
- W156615204 modified "2023-10-03" @default.
- W156615204 title "Tissue Distribution of Tetrahydrobiopterin Generating Enzymes" @default.
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- W156615204 doi "https://doi.org/10.1007/978-1-4615-2960-6_44" @default.
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