FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566160921> ?p ?o ?g. }

• W1566160921 endingPage "3093" @default.
• W1566160921 startingPage "3088" @default.
• W1566160921 abstract "Recently, we reported the purification of a 46-kDa membrane-associated platelet protein which is phosphorylated in intact platelets and platelet membranes by cGMP- and cAMP-dependent protein kinases (Halbrugge, M., and Walter, U. (1989) Eur. J. Biochem. 185, 41-50). Here we demonstrate that both cGMP- and cAMP-dependent protein kinases catalyze the rapid incorporation of up to 1.4 mol of phosphate/mol of this purified vasodilator-stimulated phosphoprotein (VASP). A specific rabbit antiserum was prepared which recognized both the 46-kDa dephospho form and the 50-kDa phospho form of VASP in Western blots. In untreated washed platelets, VASP was found to be present primarily as a 46-kDa dephosphoprotein. Sodium nitroprusside (100 microM) raised the intracellular platelet cGMP concentration from approximately 0.44 to 4.1 microM, without a significant effect on the cAMP level, and converted up to 50% of VASP to the 50-kDa phospho form. Prostaglandin E1 (10 microM) raised the platelet cAMP concentration from approximately 4.4 to 28.4 microM, without a significant effect on the cGMP level, and shifted up to 67% of VASP to the 50-kDa phospho form. Removal of the vasodilators sodium nitroprusside and prostaglandin E1 from the platelet suspension was followed by a return of the cyclic nucleotide concentration to basal levels and subsequent conversion of the 50-kDa phospho form of VASP to the 46-kDa dephospho form. The results support the hypothesis that VASP phosphorylation is an important component of the intracellular mechanism of action of these vasodilators in human platelets." @default.
• W1566160921 created "2016-06-24" @default.
• W1566160921 creator A5005040424 @default.
• W1566160921 creator A5039880161 @default.
• W1566160921 creator A5069089776 @default.
• W1566160921 creator A5072719814 @default.
• W1566160921 creator A5082432186 @default.
• W1566160921 date "1990-02-01" @default.
• W1566160921 modified "2023-10-16" @default.
• W1566160921 title "Stoichiometric and reversible phosphorylation of a 46-kDa protein in human platelets in response to cGMP- and cAMP-elevating vasodilators." @default.
• W1566160921 cites W1008579097 @default.
• W1566160921 cites W1495691424 @default.
• W1566160921 cites W1527467938 @default.
• W1566160921 cites W1548164869 @default.
• W1566160921 cites W1566938829 @default.
• W1566160921 cites W1569302170 @default.
• W1566160921 cites W1965614591 @default.
• W1566160921 cites W1967345709 @default.
• W1566160921 cites W1982461852 @default.
• W1566160921 cites W1993616390 @default.
• W1566160921 cites W2033361456 @default.
• W1566160921 cites W2066555820 @default.
• W1566160921 cites W2083529249 @default.
• W1566160921 cites W2089515621 @default.
• W1566160921 cites W2090350631 @default.
• W1566160921 cites W2092004001 @default.
• W1566160921 cites W2104380573 @default.
• W1566160921 cites W2327484480 @default.
• W1566160921 cites W333881082 @default.
• W1566160921 doi "https://doi.org/10.1016/s0021-9258(19)39737-6" @default.
• W1566160921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2154470" @default.
• W1566160921 hasPublicationYear "1990" @default.
• W1566160921 type Work @default.
• W1566160921 sameAs 1566160921 @default.
• W1566160921 citedByCount "249" @default.
• W1566160921 countsByYear W15661609212012 @default.
• W1566160921 countsByYear W15661609212013 @default.
• W1566160921 countsByYear W15661609212014 @default.
• W1566160921 countsByYear W15661609212015 @default.
• W1566160921 countsByYear W15661609212016 @default.
• W1566160921 countsByYear W15661609212017 @default.
• W1566160921 countsByYear W15661609212018 @default.
• W1566160921 countsByYear W15661609212019 @default.
• W1566160921 countsByYear W15661609212020 @default.
• W1566160921 countsByYear W15661609212022 @default.
• W1566160921 countsByYear W15661609212023 @default.
• W1566160921 crossrefType "journal-article" @default.
• W1566160921 hasAuthorship W1566160921A5005040424 @default.
• W1566160921 hasAuthorship W1566160921A5039880161 @default.
• W1566160921 hasAuthorship W1566160921A5069089776 @default.
• W1566160921 hasAuthorship W1566160921A5072719814 @default.
• W1566160921 hasAuthorship W1566160921A5082432186 @default.
• W1566160921 hasBestOaLocation W15661609211 @default.
• W1566160921 hasConcept C11960822 @default.
• W1566160921 hasConcept C120770815 @default.
• W1566160921 hasConcept C12554922 @default.
• W1566160921 hasConcept C126322002 @default.
• W1566160921 hasConcept C134018914 @default.
• W1566160921 hasConcept C144082473 @default.
• W1566160921 hasConcept C178790620 @default.
• W1566160921 hasConcept C181199279 @default.
• W1566160921 hasConcept C185592680 @default.
• W1566160921 hasConcept C3020139451 @default.
• W1566160921 hasConcept C55493867 @default.
• W1566160921 hasConcept C71924100 @default.
• W1566160921 hasConcept C86803240 @default.
• W1566160921 hasConcept C87325107 @default.
• W1566160921 hasConcept C89560881 @default.
• W1566160921 hasConcept C95444343 @default.
• W1566160921 hasConcept C97029542 @default.
• W1566160921 hasConceptScore W1566160921C11960822 @default.
• W1566160921 hasConceptScore W1566160921C120770815 @default.
• W1566160921 hasConceptScore W1566160921C12554922 @default.
• W1566160921 hasConceptScore W1566160921C126322002 @default.
• W1566160921 hasConceptScore W1566160921C134018914 @default.
• W1566160921 hasConceptScore W1566160921C144082473 @default.
• W1566160921 hasConceptScore W1566160921C178790620 @default.
• W1566160921 hasConceptScore W1566160921C181199279 @default.
• W1566160921 hasConceptScore W1566160921C185592680 @default.
• W1566160921 hasConceptScore W1566160921C3020139451 @default.
• W1566160921 hasConceptScore W1566160921C55493867 @default.
• W1566160921 hasConceptScore W1566160921C71924100 @default.
• W1566160921 hasConceptScore W1566160921C86803240 @default.
• W1566160921 hasConceptScore W1566160921C87325107 @default.
• W1566160921 hasConceptScore W1566160921C89560881 @default.
• W1566160921 hasConceptScore W1566160921C95444343 @default.
• W1566160921 hasConceptScore W1566160921C97029542 @default.
• W1566160921 hasIssue "6" @default.
• W1566160921 hasLocation W15661609211 @default.
• W1566160921 hasOpenAccess W1566160921 @default.
• W1566160921 hasPrimaryLocation W15661609211 @default.
• W1566160921 hasRelatedWork W1964894777 @default.
• W1566160921 hasRelatedWork W2000032212 @default.
• W1566160921 hasRelatedWork W2037796657 @default.
• W1566160921 hasRelatedWork W2046136285 @default.
• W1566160921 hasRelatedWork W2055602123 @default.
• W1566160921 hasRelatedWork W2060357870 @default.
• W1566160921 hasRelatedWork W2409892889 @default.

• next