Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566163765> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1566163765 endingPage "6002" @default.
- W1566163765 startingPage "5993" @default.
- W1566163765 abstract "A cell-free system, consisting of particle-free cytoplasm and mitochondria prepared from rat liver, has been used to study the transfer of acetyl groups from the intramitochondrial to the extramitochondrial space during fatty acid synthesis. 14C-Pyruvate, generated from 14C-alanine, was used to generate intramitochondrial 14C-acetyl-CoA. Fatty acid synthesis was followed by measuring the incorporation of 3H2O and 14C. Pool dilution experiments showed that the acetyl group of intramitochondrial acetyl-CoA leaves the mitochondria in the form of citrate, or of a closely related tricarboxylate. (-)-Hydroxycitrate, an inhibitor of citrate cleavage enzyme, strongly inhibits fatty acid synthesis from 14C-alanine. On the other hand, (-)-hydroxycitrate has little or no effect on respiration, phosphorylation, and citrate accumulation during the course of the experiments. n-Butylmalonate, an inhibitor of malate permease, also inhibits fatty acid synthesis. This inhibition is reversed by malate. n-Butylmalonate probably exerts its effect by preventing the activation of α-ketoglutarate and tricarboxylate permeases by malate. It is concluded that citrate is the major carrier in the transfer of acetyl groups from the mitochondrial matrix to the cytoplasm." @default.
- W1566163765 created "2016-06-24" @default.
- W1566163765 creator A5029658678 @default.
- W1566163765 creator A5067334427 @default.
- W1566163765 date "1970-11-01" @default.
- W1566163765 modified "2023-10-15" @default.
- W1566163765 title "Citrate and the Conversion of Carbohydrate into Fat" @default.
- W1566163765 cites W10140315 @default.
- W1566163765 cites W14247201 @default.
- W1566163765 cites W1542661598 @default.
- W1566163765 cites W1566829633 @default.
- W1566163765 cites W1769215855 @default.
- W1566163765 cites W1947915694 @default.
- W1566163765 cites W1966929750 @default.
- W1566163765 cites W200185773 @default.
- W1566163765 cites W2039240947 @default.
- W1566163765 cites W2045183285 @default.
- W1566163765 cites W2085536106 @default.
- W1566163765 cites W2232834895 @default.
- W1566163765 cites W2402976707 @default.
- W1566163765 cites W2409213961 @default.
- W1566163765 cites W2413529871 @default.
- W1566163765 cites W46974184 @default.
- W1566163765 doi "https://doi.org/10.1016/s0021-9258(18)62653-5" @default.
- W1566163765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5484459" @default.
- W1566163765 hasPublicationYear "1970" @default.
- W1566163765 type Work @default.
- W1566163765 sameAs 1566163765 @default.
- W1566163765 citedByCount "198" @default.
- W1566163765 countsByYear W15661637652012 @default.
- W1566163765 countsByYear W15661637652013 @default.
- W1566163765 countsByYear W15661637652014 @default.
- W1566163765 countsByYear W15661637652015 @default.
- W1566163765 countsByYear W15661637652016 @default.
- W1566163765 countsByYear W15661637652017 @default.
- W1566163765 countsByYear W15661637652018 @default.
- W1566163765 countsByYear W15661637652019 @default.
- W1566163765 countsByYear W15661637652020 @default.
- W1566163765 countsByYear W15661637652021 @default.
- W1566163765 countsByYear W15661637652022 @default.
- W1566163765 countsByYear W15661637652023 @default.
- W1566163765 crossrefType "journal-article" @default.
- W1566163765 hasAuthorship W1566163765A5029658678 @default.
- W1566163765 hasAuthorship W1566163765A5067334427 @default.
- W1566163765 hasBestOaLocation W15661637651 @default.
- W1566163765 hasConcept C17093226 @default.
- W1566163765 hasConcept C185592680 @default.
- W1566163765 hasConcept C2778977261 @default.
- W1566163765 hasConcept C31903555 @default.
- W1566163765 hasConcept C55493867 @default.
- W1566163765 hasConceptScore W1566163765C17093226 @default.
- W1566163765 hasConceptScore W1566163765C185592680 @default.
- W1566163765 hasConceptScore W1566163765C2778977261 @default.
- W1566163765 hasConceptScore W1566163765C31903555 @default.
- W1566163765 hasConceptScore W1566163765C55493867 @default.
- W1566163765 hasIssue "22" @default.
- W1566163765 hasLocation W15661637651 @default.
- W1566163765 hasOpenAccess W1566163765 @default.
- W1566163765 hasPrimaryLocation W15661637651 @default.
- W1566163765 hasRelatedWork W1531601525 @default.
- W1566163765 hasRelatedWork W2007709060 @default.
- W1566163765 hasRelatedWork W2055819249 @default.
- W1566163765 hasRelatedWork W2260388265 @default.
- W1566163765 hasRelatedWork W2421443640 @default.
- W1566163765 hasRelatedWork W2611314341 @default.
- W1566163765 hasRelatedWork W2748952813 @default.
- W1566163765 hasRelatedWork W2899084033 @default.
- W1566163765 hasRelatedWork W2993834730 @default.
- W1566163765 hasRelatedWork W1875134308 @default.
- W1566163765 hasVolume "245" @default.
- W1566163765 isParatext "false" @default.
- W1566163765 isRetracted "false" @default.
- W1566163765 magId "1566163765" @default.
- W1566163765 workType "article" @default.