Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566165116> ?p ?o ?g. }
- W1566165116 endingPage "764" @default.
- W1566165116 startingPage "757" @default.
- W1566165116 abstract "The cancer stem cell (CSC) model is based on a myriad of experimental and clinical observations suggesting that the malignant phenotype is sustained by a subset of cells characterized by the capacity for self-renewal, differentiation and innate resistance to chemotherapy and radiation. CSC may be responsible for disease recurrence after definitive therapy and may therefore be functionally synonymous with minimal residual disease. Similar to other solid tumours, several putative surface markers for lung CSC have been identified, including CD133 and CD44. In addition, expression and/or activity of the cytoplasmic enzyme aldehyde dehydrogenase ALDH and capacity of cells to exclude membrane permeable dyes (known as the 'side population') correlate with stem-like function in vitro and in vivo. Embryonic stem cell pathways such as Hedgehog, Notch and WNT may also be active in lung cancers stem cells and therefore may be therapeutically targetable for maintenance therapy in patients achieving a complete response to surgery, radiotherapy or chemotherapy. This paper will review the evidence regarding the existence and function of lung CSC in the context of the experimental and clinical evidence and discuss some ongoing controversies regarding this model." @default.
- W1566165116 created "2016-06-24" @default.
- W1566165116 creator A5018587056 @default.
- W1566165116 creator A5020706368 @default.
- W1566165116 creator A5022491020 @default.
- W1566165116 creator A5027419360 @default.
- W1566165116 creator A5047668510 @default.
- W1566165116 date "2013-06-21" @default.
- W1566165116 modified "2023-10-01" @default.
- W1566165116 title "Cancer stem cells in lung cancer: Evidence and controversies" @default.
- W1566165116 cites W133253872 @default.
- W1566165116 cites W1481967818 @default.
- W1566165116 cites W1495710350 @default.
- W1566165116 cites W1885320430 @default.
- W1566165116 cites W1966166667 @default.
- W1566165116 cites W1968627142 @default.
- W1566165116 cites W1972079160 @default.
- W1566165116 cites W1975306683 @default.
- W1566165116 cites W1975727847 @default.
- W1566165116 cites W1978405268 @default.
- W1566165116 cites W1979547093 @default.
- W1566165116 cites W1981539168 @default.
- W1566165116 cites W1983357205 @default.
- W1566165116 cites W1986034385 @default.
- W1566165116 cites W1988459185 @default.
- W1566165116 cites W1990757263 @default.
- W1566165116 cites W1994599132 @default.
- W1566165116 cites W1995004385 @default.
- W1566165116 cites W1997379399 @default.
- W1566165116 cites W2001544973 @default.
- W1566165116 cites W2002784005 @default.
- W1566165116 cites W2002937040 @default.
- W1566165116 cites W2007252845 @default.
- W1566165116 cites W2007859564 @default.
- W1566165116 cites W2009886857 @default.
- W1566165116 cites W2011271039 @default.
- W1566165116 cites W2012101115 @default.
- W1566165116 cites W2013614359 @default.
- W1566165116 cites W2022881840 @default.
- W1566165116 cites W2023028445 @default.
- W1566165116 cites W2023316892 @default.
- W1566165116 cites W2023427658 @default.
- W1566165116 cites W2024505724 @default.
- W1566165116 cites W2033990975 @default.
- W1566165116 cites W2045476312 @default.
- W1566165116 cites W2045927984 @default.
- W1566165116 cites W2050034880 @default.
- W1566165116 cites W2050634684 @default.
- W1566165116 cites W2051055358 @default.
- W1566165116 cites W2052461136 @default.
- W1566165116 cites W2055296003 @default.
- W1566165116 cites W2061029215 @default.
- W1566165116 cites W2065277366 @default.
- W1566165116 cites W2072778582 @default.
- W1566165116 cites W2073551059 @default.
- W1566165116 cites W2073656127 @default.
- W1566165116 cites W2081735359 @default.
- W1566165116 cites W2084488214 @default.
- W1566165116 cites W2084564750 @default.
- W1566165116 cites W2084996794 @default.
- W1566165116 cites W2088594738 @default.
- W1566165116 cites W2090176557 @default.
- W1566165116 cites W2090982381 @default.
- W1566165116 cites W2091519635 @default.
- W1566165116 cites W2102085111 @default.
- W1566165116 cites W2104098330 @default.
- W1566165116 cites W2104666893 @default.
- W1566165116 cites W2107029930 @default.
- W1566165116 cites W2107394975 @default.
- W1566165116 cites W2108035852 @default.
- W1566165116 cites W2113327188 @default.
- W1566165116 cites W2118933841 @default.
- W1566165116 cites W2129124160 @default.
- W1566165116 cites W2129375080 @default.
- W1566165116 cites W2133117291 @default.
- W1566165116 cites W2134386050 @default.
- W1566165116 cites W2137715553 @default.
- W1566165116 cites W2137956382 @default.
- W1566165116 cites W2138793636 @default.
- W1566165116 cites W2145967409 @default.
- W1566165116 cites W2146949185 @default.
- W1566165116 cites W2151879335 @default.
- W1566165116 cites W2152043634 @default.
- W1566165116 cites W2152627545 @default.
- W1566165116 cites W2153798985 @default.
- W1566165116 cites W2154861644 @default.
- W1566165116 cites W2161563128 @default.
- W1566165116 cites W2167017433 @default.
- W1566165116 cites W2168674395 @default.
- W1566165116 cites W2245020166 @default.
- W1566165116 cites W2965042402 @default.
- W1566165116 doi "https://doi.org/10.1111/resp.12094" @default.
- W1566165116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3991120" @default.
- W1566165116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23586700" @default.
- W1566165116 hasPublicationYear "2013" @default.
- W1566165116 type Work @default.
- W1566165116 sameAs 1566165116 @default.
- W1566165116 citedByCount "117" @default.