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• W1566182575 startingPage "2689" @default.
• W1566182575 abstract "Infection with Mycobacterium tuberculosis induces Abs against a vast array of mycobacterial lipids and glycolipids. One of the most prominent lipid Ags recognized is cardiolipin (CL). The kinetics of the generation of anti-CL Abs during infection reveals that IgM titers to CL increase over time. Interestingly, at day 30 postinfection CL-specific IgG1 appears, an isotype usually dependent on T cell help. Using an immunization schedule with CL/anti-CL Ab complexes, which induces antiphospholipid syndrome in mice, we show that the generation of IgG1 to CL requires IL-4 and that optimal production is T cell dependent. IgG1 production to CL was impaired in nude (nu/nu) mice devoid in conventional T cells, but was not affected in mice deficient for either alphabeta TCR(+), gammadelta TCR(+), CD4(+), CD8(+), or NK1.1(+) T cells. We conclude that IgG1 production to CL depends on T cell help and IL-4, which can be provided by different T cell populations. This is the first report that IL-4 is indispensable for the induction of IgG1 Abs to lipid Ags." @default.
• W1566182575 created "2016-06-24" @default.
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• W1566182575 date "2002-03-15" @default.
• W1566182575 modified "2023-10-01" @default.
• W1566182575 title "IL-4 and T Cells Are Required for the Generation of IgG1 Isotype Antibodies Against Cardiolipin" @default.
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• W1566182575 doi "https://doi.org/10.4049/jimmunol.168.6.2689" @default.
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