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- W1566187056 abstract "One hundred and twenty sexually mature male and female rats were divided into three groups (control and treated with 5 mcg. or 100 mcg. for 30 days). Results indicate a significant increase (P < 0.001) in prostate weights of twofold over those of the controls. Seminal vesicle and testes weights of the treated animals experienced no significant changes. The prostate increase is due to hyperplasia, as documented by histologic study. The lead concentration in the blood was 14.1 mcg. per 100 ml. for the control group and 19 and 30 mcg. per 100 ml. in the treated groups. The females treated with 5 mcg. of lead acetate experienced irregularity of the estrus cycle, while the group treated with 100 mcg. had persistent vaginal estrus after a period of normal estrus, and the development of ovarian follicular cysts with a reduction in the number of corpora lutea was noted. Both male and female treated animals showed an inhibition of hepatic microsomal activity (drug detoxification mechanism). These results indicate the possibility of hazardous effects of lead acetate (depending on the dosage and period of exposure) on sexuality and reproductive function." @default.
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- W1566187056 date "1973-04-01" @default.
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- W1566187056 title "Effect of lead acetate on reproduction" @default.
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- W1566187056 doi "https://doi.org/10.1016/0002-9378(73)90554-1" @default.
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