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- W1566194527 abstract "The mammalian heart is known to undergo significant mechanical changes during fetal and neonatal development. The objective of this study was to define the ontogeny of the ryanodine receptor/ release channel and SERCA that play the major roles in excitation-contraction coupling. Whole ventricular homogenates of fetal (F) (19 and 22 days in gestation), postnatal (N) (1 and 7 days postnatal), and adult (A) (5 weeks postnatal) Sprague-Dawley rat hearts were used to study []ryanodine binding and oxalate-supported uptake. For the ryanodine receptor, the major findings were: (1) The ryanodine receptor density, as determined by maximal []ryanodine binding (), increased 3 fold between the F22 and A periods ( vs. pmoles/mg protein, p vs. ). (2) Affinity of the ryanodine receptor to ryanodine did not significantly change, as suggested by the lack of change in the during the development and maturation. For SERCA, changes started early with an increased rate of uptake in the fetal periods (F19: vs. F22: nmoles/g protein/min; p). Thus, we conclude that the quantitative changes occur in the ryanodine receptor during myocardial development. Also, the maturation of the uptake appears to start earlier than that of the release." @default.
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- W1566194527 date "2001-11-30" @default.
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- W1566194527 title "Characterization of the Ryanodine Receptor and SERCA in Fetal, Neonatal, and Adult Rat Hearts" @default.
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