Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566218302> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1566218302 endingPage "84" @default.
- W1566218302 startingPage "577" @default.
- W1566218302 abstract "Phosphorylcholine (PC) may play an important role in the atherogenic and pro-inflammatory effects of oxidized low density lipoproteins. We recently demonstrated that low levels of IgM antibodies against PC (anti-PC) are associated with development of myocardial infarction and stroke. We here evaluate the association between anti-PC and dementia and Alzheimer's disease (AD). We conducted a nested case-control study of 182 incident dementia cases (serum collected before onset of dementia) matched to 366 controls and a case-control study of 97 prevalent dementia cases (serum collected after dementia onset) matched to 205 controls. Controls were matched on gender and age at blood draw (+/- 1 year). Participants were from the Swedish Twin Registry. Anti-PC levels were measured by ELISA. The odds ratio (OR) of dementia was modeled using conditional logistic regression. Patients with dementia had significantly lower mean anti-PC levels than controls (39.1 versus 49.5 U/ml). The likelihood of having dementia or AD was doubled for individuals with the lowest 25% anti-PC levels (OR=2.04 and 2.70, respectively). The results were similar after adjustments for potential confounders. There was no association between anti-PC levels and incident dementia. Low levels of atheroprotective anti-PC could play a role in AD and dementia. Potential mechanisms include decreased anti-inflammatory potential and effects on the vasculature. Further attention is merited to elucidate the role of anti-PC in AD development and the usefulness of anti-PC as a part of risk prediction, prognosis, diagnosis, or treatment." @default.
- W1566218302 created "2016-06-24" @default.
- W1566218302 creator A5002237505 @default.
- W1566218302 creator A5011350655 @default.
- W1566218302 creator A5026423990 @default.
- W1566218302 creator A5045299069 @default.
- W1566218302 creator A5082785548 @default.
- W1566218302 creator A5087484937 @default.
- W1566218302 date "2010-01-01" @default.
- W1566218302 modified "2023-10-17" @default.
- W1566218302 title "Low levels of antibodies against phosphorylcholine in Alzheimer's disease." @default.
- W1566218302 doi "https://doi.org/10.3233/jad-2010-091705" @default.
- W1566218302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20571218" @default.
- W1566218302 hasPublicationYear "2010" @default.
- W1566218302 type Work @default.
- W1566218302 sameAs 1566218302 @default.
- W1566218302 citedByCount "13" @default.
- W1566218302 countsByYear W15662183022012 @default.
- W1566218302 countsByYear W15662183022013 @default.
- W1566218302 countsByYear W15662183022014 @default.
- W1566218302 countsByYear W15662183022015 @default.
- W1566218302 countsByYear W15662183022016 @default.
- W1566218302 countsByYear W15662183022017 @default.
- W1566218302 countsByYear W15662183022020 @default.
- W1566218302 countsByYear W15662183022022 @default.
- W1566218302 crossrefType "journal-article" @default.
- W1566218302 hasAuthorship W1566218302A5002237505 @default.
- W1566218302 hasAuthorship W1566218302A5011350655 @default.
- W1566218302 hasAuthorship W1566218302A5026423990 @default.
- W1566218302 hasAuthorship W1566218302A5045299069 @default.
- W1566218302 hasAuthorship W1566218302A5082785548 @default.
- W1566218302 hasAuthorship W1566218302A5087484937 @default.
- W1566218302 hasConcept C126322002 @default.
- W1566218302 hasConcept C146304588 @default.
- W1566218302 hasConcept C151956035 @default.
- W1566218302 hasConcept C156957248 @default.
- W1566218302 hasConcept C165617652 @default.
- W1566218302 hasConcept C203014093 @default.
- W1566218302 hasConcept C2776833585 @default.
- W1566218302 hasConcept C2777952318 @default.
- W1566218302 hasConcept C2779134260 @default.
- W1566218302 hasConcept C2779483572 @default.
- W1566218302 hasConcept C2779662715 @default.
- W1566218302 hasConcept C502032728 @default.
- W1566218302 hasConcept C55493867 @default.
- W1566218302 hasConcept C71924100 @default.
- W1566218302 hasConcept C77350462 @default.
- W1566218302 hasConcept C86803240 @default.
- W1566218302 hasConceptScore W1566218302C126322002 @default.
- W1566218302 hasConceptScore W1566218302C146304588 @default.
- W1566218302 hasConceptScore W1566218302C151956035 @default.
- W1566218302 hasConceptScore W1566218302C156957248 @default.
- W1566218302 hasConceptScore W1566218302C165617652 @default.
- W1566218302 hasConceptScore W1566218302C203014093 @default.
- W1566218302 hasConceptScore W1566218302C2776833585 @default.
- W1566218302 hasConceptScore W1566218302C2777952318 @default.
- W1566218302 hasConceptScore W1566218302C2779134260 @default.
- W1566218302 hasConceptScore W1566218302C2779483572 @default.
- W1566218302 hasConceptScore W1566218302C2779662715 @default.
- W1566218302 hasConceptScore W1566218302C502032728 @default.
- W1566218302 hasConceptScore W1566218302C55493867 @default.
- W1566218302 hasConceptScore W1566218302C71924100 @default.
- W1566218302 hasConceptScore W1566218302C77350462 @default.
- W1566218302 hasConceptScore W1566218302C86803240 @default.
- W1566218302 hasIssue "2" @default.
- W1566218302 hasLocation W15662183021 @default.
- W1566218302 hasLocation W15662183022 @default.
- W1566218302 hasOpenAccess W1566218302 @default.
- W1566218302 hasPrimaryLocation W15662183021 @default.
- W1566218302 hasRelatedWork W1533990758 @default.
- W1566218302 hasRelatedWork W1566218302 @default.
- W1566218302 hasRelatedWork W1859821439 @default.
- W1566218302 hasRelatedWork W1978203409 @default.
- W1566218302 hasRelatedWork W2356355095 @default.
- W1566218302 hasRelatedWork W2757957113 @default.
- W1566218302 hasRelatedWork W2789433985 @default.
- W1566218302 hasRelatedWork W313460363 @default.
- W1566218302 hasRelatedWork W3205111497 @default.
- W1566218302 hasRelatedWork W2111983495 @default.
- W1566218302 hasVolume "21" @default.
- W1566218302 isParatext "false" @default.
- W1566218302 isRetracted "false" @default.
- W1566218302 magId "1566218302" @default.
- W1566218302 workType "article" @default.