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• W156622937 endingPage "91" @default.
• W156622937 startingPage "81" @default.
• W156622937 abstract "Advances since my last review in 1998 on our understanding of the effects of heat on the testis are summarized. Techniques used to study these effects have included exposing the whole animal to a hot environment, insulation of the whole scrotum or just its neck, immersing the testes in a warm water bath, surgically returning one or both testes to the abdominal cavity (induced cryptorchidism) or exposing them to microwave radiation. Most techniques have been shown to affect principally primary spermatocytes and early spermatids, but there is some evidence for effects on spermatogonia and Sertoli cells. The Leydig cells and androgen secretion do not appear to be directly affected. There is considerable variation in susceptibility between individual animals and between different strains, which appears to be due to differences in the ability of the animals to maintain testis temperature as well as in inherent susceptibility of the different germ cells. The mechanism of cell death appears to be apoptosis, not necrosis, and may involve reactive oxygen species (ROS), the tumour suppressor protein p53, nitric oxide synthase (NOS), the translocation of the proapototic factor Bax from the cytoplasm to a perinuclear position, the release of cytochrome c from mitochondria and several caspases. Animals deficient in Fas and Fas ligand appear still to be susceptible, making it unlikely that these factors are involved. Although many authors believe that the effects of heat are fully reversible, there is now evidence of long-term effects, following either locally applied heat or temporary induced cryptorchidism. These long-term effects appear to be different from those seen following irradiation, and may indicate a failure of Sertoli cell function. Sperm produced by mice which had been exposed to a hot environment bind to ova normally but are less able to fertilize in vivo and in vitro, even when motile sperm are selected by a swim-up procedure, and many of the resultant embryos do not develop normally. Blocking caspase activity or release of cytochrome c reduced the effect of heat. Mice lacking iNOS were more resistant to the effects of local testicular heating, and inhibitors of xanthine oxidase (an enzyme important in the production of ROS) reduced the effects of making the testis cryptorchid, while mice in which the gene for superoxide dismutase (SOD1, which is involved in the breakdown of ROS) had been knocked out were more sensitive. Treatment of rats with pregnant mare serum gonadotropin, thyroxin or low doses of testosterone increased the time at which infertility began following testicular heating. Treatment with vitamin E or PBN (Ntert-butyl-α- phenylnitrone, a free radical spin trap but also a possible source of NO) decreased the effects of local testicular heating on testis weight, while ascorbic acid had no effect; in contrast treatment with PBN increased the effect of temporary induced cryptorchidism. The most surprising finding was that induced cryptorchidism actually improved spermatogenesis in juvenile spermatogonial depletion (jsd) mice and to some extent in previously irradiated mice and rats treated with hexanedione." @default.
• W156622937 created "2016-06-24" @default.
• W156622937 creator A5083966337 @default.
• W156622937 date "2006-01-01" @default.
• W156622937 modified "2023-09-26" @default.
• W156622937 title "The effects of heat on the testes of mammals" @default.
• W156622937 cites W132743638 @default.
• W156622937 cites W1537778521 @default.
• W156622937 cites W1552748159 @default.
• W156622937 cites W1571465601 @default.
• W156622937 cites W1584624964 @default.
• W156622937 cites W1590461098 @default.
• W156622937 cites W173732388 @default.
• W156622937 cites W1899695051 @default.
• W156622937 cites W1963631841 @default.
• W156622937 cites W1964602940 @default.
• W156622937 cites W1965545374 @default.
• W156622937 cites W1968869201 @default.
• W156622937 cites W1971564913 @default.
• W156622937 cites W1972889589 @default.
• W156622937 cites W1975493095 @default.
• W156622937 cites W1980214425 @default.
• W156622937 cites W1982100349 @default.
• W156622937 cites W1984282362 @default.
• W156622937 cites W1984647519 @default.
• W156622937 cites W1988538310 @default.
• W156622937 cites W1990084062 @default.
• W156622937 cites W1990229537 @default.
• W156622937 cites W1991390604 @default.
• W156622937 cites W1996694848 @default.
• W156622937 cites W1997386394 @default.
• W156622937 cites W2001507834 @default.
• W156622937 cites W2001713346 @default.
• W156622937 cites W2005478008 @default.
• W156622937 cites W2005984475 @default.
• W156622937 cites W2006327112 @default.
• W156622937 cites W2008301952 @default.
• W156622937 cites W2008712368 @default.
• W156622937 cites W2009377179 @default.
• W156622937 cites W2009630207 @default.
• W156622937 cites W2010582753 @default.
• W156622937 cites W2015563533 @default.
• W156622937 cites W2018523160 @default.
• W156622937 cites W2020905122 @default.
• W156622937 cites W2022483705 @default.
• W156622937 cites W2027704751 @default.
• W156622937 cites W2027755493 @default.
• W156622937 cites W2029276689 @default.
• W156622937 cites W2030045980 @default.
• W156622937 cites W2030748096 @default.
• W156622937 cites W2035954457 @default.
• W156622937 cites W2039769257 @default.
• W156622937 cites W2045616407 @default.
• W156622937 cites W2046131551 @default.
• W156622937 cites W2048838533 @default.
• W156622937 cites W2049982824 @default.
• W156622937 cites W2051425047 @default.
• W156622937 cites W2053745188 @default.
• W156622937 cites W2054030175 @default.
• W156622937 cites W2055988619 @default.
• W156622937 cites W2057818632 @default.
• W156622937 cites W2062263569 @default.
• W156622937 cites W2062674411 @default.
• W156622937 cites W2065367796 @default.
• W156622937 cites W2069708257 @default.
• W156622937 cites W2072334584 @default.
• W156622937 cites W2075596079 @default.
• W156622937 cites W2087807900 @default.
• W156622937 cites W2089499612 @default.
• W156622937 cites W2089798513 @default.
• W156622937 cites W2090310697 @default.
• W156622937 cites W2091030425 @default.
• W156622937 cites W2091044340 @default.
• W156622937 cites W2097615056 @default.
• W156622937 cites W2097939257 @default.
• W156622937 cites W2099349123 @default.
• W156622937 cites W2099860833 @default.
• W156622937 cites W2100142976 @default.
• W156622937 cites W2104402660 @default.
• W156622937 cites W2105627924 @default.
• W156622937 cites W2105818850 @default.
• W156622937 cites W2113372352 @default.
• W156622937 cites W2114709461 @default.
• W156622937 cites W2115967293 @default.
• W156622937 cites W2120876317 @default.
• W156622937 cites W2122050600 @default.
• W156622937 cites W2125934950 @default.
• W156622937 cites W2126566547 @default.
• W156622937 cites W2130558170 @default.
• W156622937 cites W2130614519 @default.
• W156622937 cites W2139113562 @default.
• W156622937 cites W2144514579 @default.
• W156622937 cites W2146723642 @default.
• W156622937 cites W2150297267 @default.
• W156622937 cites W2158383624 @default.
• W156622937 cites W2160413910 @default.
• W156622937 cites W2161842991 @default.
• W156622937 cites W2163361736 @default.

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