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- W1566233757 abstract "This chapter covers a broad range of statistical methods for dose finding in drug-combination trials. The sequential scheme is a straightforward approach to designing a two-drug combination trial, which can be coupled with any single-agent dose-finding method. The copula-type design has an elegant structure, which reduces to the single-agent continual reassessment method (CRM) if only one drug is tested. The latent 2 x 2 table approach can easily incorporate correlations or interactions between the two drugs in combination, but the likelihood degenerates to a binomial distribution due to a lack of information on toxicities attributable to each drug. In a phase I/II drug-combination trial, the author models both toxicity and efficacy, which in fact is more natural because it need to determine the most effective one among multiple identified maximum tolerated dose (MTD) combinations due to toxicity equivalence contours. Controlled Vocabulary Terms copula; likelihood; sequential analysis; statistical measures" @default.
- W1566233757 created "2016-06-24" @default.
- W1566233757 creator A5080151722 @default.
- W1566233757 date "2011-12-19" @default.
- W1566233757 modified "2023-09-26" @default.
- W1566233757 title "Drug‐Combination Trials" @default.
- W1566233757 doi "https://doi.org/10.1002/9781118183335.ch9" @default.
- W1566233757 hasPublicationYear "2011" @default.
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