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• W1566239063 abstract "A 67‐year‐old male living in T su city, M ie prefecture, J apan was referred to our hospital for further examination of acute liver injury and was diagnosed as having clinical hepatitis E virus ( HEV ) infection in J anuary 2010. The HEV strain ( HE ‐ JA11 ‐1701) isolated from the patient belonged to genotype 3 and European‐type subgenotype 3e. It was presumed that the patient had been infected from a wild boar ( S us scrofa leucomystax ) because he consumed meat/viscera from a wild boar that he had captured himself as a hunter approximately 2 months before disease onset. A specimen of the boar meat/viscera that the patient had ingested was not available. However, the HE ‐ JA11 ‐1701 strain was 99.8% identical within the 412‐nucleotide sequence of the open reading frame 2 region to a HEV strain ( JBOAR012‐Mie08 ) that had been recovered from a wild boar captured near the patient's hunting area in 2008. A phylogenetic analysis confirmed that the two HEV strains had a close genetic relationship and were segregated into subgenotype 3e, supported by a high bootstrap value of 99%. Of note, the HE ‐ JA11 ‐1701 and JBOAR012 ‐ Mie08 strains were remotely related to the 3e strains reported in J apan and European countries, with a nucleotide difference of 7.9–13.9%, reinforcing the uniqueness of the 3e strains obtained in the present study. These results strongly support our speculation that the patient developed acute hepatitis E via consumption of HEV ‐infected boar meat/viscera. Genetic analyses of HEV strains are useful for tracing infectious sources in sporadic cases of acute hepatitis E ." @default.
• W1566239063 created "2016-06-24" @default.
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• W1566239063 date "2013-05-27" @default.
• W1566239063 modified "2023-10-17" @default.
• W1566239063 title "High genomic similarity between European type hepatitis E virus subgenotype 3e strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan" @default.
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• W1566239063 doi "https://doi.org/10.1111/hepr.12155" @default.
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