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• W1566255047 abstract "OF THESIS INTERLEUKIN-10 RECEPTOR DYSFUNCTION IN PERITONEAL MACROPHAGES BY TOLL-LIKE RECEPTOR LIGANDS Interleukin-10 (IL-10) is a pleiotropic cytokine which limits inflammatory responses by balancing the host’s immune response against infection. Mammalian Toll-like receptors (TLRs) are pattern recognition receptors that recognize specific molecular pattens on microbial pathogens and activate intracellular signaling via the transcription factors NF-κB and IRF-3. In this study we evaluate the contribution of the TLR ligands Poly I:C, Pam 3 CSK4, LPS and LTA to IL-10 receptor dysfunction in murine peritoneal macrophages (PM). We examine how these ligands are able to alter IL-10 mediated STAT3 phosphorylation and CCR5 gene expression in PM. The ability of Poly I:C and Pam 3 CSK4 to alter the immunosuppressive activity of IL-10 in C2-ceramide stimulated PM is also examined. The results of our study indicate a delayed inhibition of IL-10 mediated activation of STAT3 by LPS, LTA, Poly I:C and Pam 3 CSK4. The CCR5 gene expression experiments demonstrate that LPS was able to down-regulate IL-10 induced CCR5 mRNA expression in PM." @default.
• W1566255047 created "2016-06-24" @default.
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• W1566255047 date "2005-01-01" @default.
• W1566255047 modified "2023-09-27" @default.
• W1566255047 title "INTERLEUKIN-10 RECEPTOR DYSFUNCTION IN PERITONEAL MACROPHAGES BY TOLL-LIKE RECEPTOR LIGANDS" @default.
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