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• W1566264851 abstract "Human immunodeficiency virus (HIV), a retrovirus that was clinically detected in 1980 and demonstrated to be the causative agent of acquired immunodeficiency syndrome (AIDS), had resulted in over 25 million deaths by 2005. Currently, more than 33 million people are HIV-positive, and approximately 2.6 million people were newly infected and 1.8 million died of AIDS-related disorders in 2009. Antiretroviral therapy (ART), available from the mid-1990s, greatly improves the quality of life for HIV-infected persons and reduces mortality. However, there are several limitations to obtaining recovery from HIV infection including drug resistance, high rate of viral mutations, limited number of targets, low bioavailability of some compounds, presence of viral reservoirs and severe side-effects. The inability of standard highly active anti-retroviral therapy (HAART) drugs to penetrate some cells ensures that virus replication continues, although the common viral load can be reduced to undetectable levels [Finzi, 1997]. In addition, owing to the high cost and complexity of current HIV therapies, fewer than 5% of HIV infected patients worldwide receive antiretroviral treatment, and in underdeveloped countries access to such drugs is severely restricted. Therefore, development of preventive and therapeutic vaccines represents a tremendous challenge to AIDS researchers. In Europe the elaboration of new therapies is one of the main goals and several studies have concerned nanotechnology, with gene therapy being proposed as a good alternative that can efficiently inhibit gene expression in a sequencespecific manner. Dendrimers, a new class of polymeric molecules, are potential candidates for developing preventive antiretroviral vaccines where the delivery vehicles have low level cytotoxicity and targeted action. The aim of this chapter is to summarize studies concerning dendrimers and their application as therapy against HIV-1." @default.
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• W1566264851 date "2011-07-27" @default.
• W1566264851 modified "2023-09-23" @default.
• W1566264851 title "Dendrimers in Anti-HIV Therapy" @default.
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• W1566264851 doi "https://doi.org/10.5772/17027" @default.
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