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- W1566265989 abstract "Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the western world with its incidence increasing lately in developing countries. Several lines of evidence support a role for inflammation in atherogenesis. Hence, dietary micronutrients having antiinflammatory properties may have a potential beneficial effect with regard to CVD. Vitamin E is a potent antioxidant with antiinflammatory properties. It comprises eight different isoforms: four tocopherols (T) (α, β, γ, and δ) and four tocotrienols (T3) (α, β, γ, and δ). A wealth of data is available for the preventive efficacy of α‐T. α‐T supplementation in human subjects and animal models has been shown to be antioxidant and antiinflammatory in terms of decreasing C‐reactive protein (CRP) and release of proinflammatory cytokines, the chemokine IL‐8 and PAI‐1 levels especially at high doses. γ‐T is effective in decreasing reactive nitrogen species and also appears to have antiinflammatory properties; however, there are scanty data examining pure γ‐T preparations. Furthermore, tocotrienols (α and γ) also have implications for prevention of CVD; however, there are conflicting and insufficient data in the literature with regards to their potency. In this chapter, we have gathered recent emerging data on α‐T specifically and also have given a composite view of γ‐T and tocotrienols especially with regards to their effect on inflammation as it relates to CVD." @default.
- W1566265989 created "2016-06-24" @default.
- W1566265989 creator A5011782005 @default.
- W1566265989 creator A5025998099 @default.
- W1566265989 date "2007-01-01" @default.
- W1566265989 modified "2023-10-16" @default.
- W1566265989 title "Vitamin E: Inflammation and Atherosclerosis" @default.
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