Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566267517> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1566267517 endingPage "1247" @default.
- W1566267517 startingPage "1240" @default.
- W1566267517 abstract "We have investigated the effect of oxidants on ligand recognition and internalization by the macrophage mannose receptor. Rat bone marrow macrophages were treated with increasing concentrations of H2O2 for 30 min at 37 degrees C. Fifty percent inhibition of ligand uptake was observed at 250 microM, with only 10% of control uptake remaining following exposure to 1 mM H2O2 for 30 min. Electron micrographic analysis of macrophages following H2O2 treatment showed no morphological alterations compared to untreated cells. Ligand uptake was also inhibited by the following H2O2 generating systems: menadione, xanthine/xanthine oxidase, glucose/glucose oxidase, and phorbol 12-myristate 13-acetate-stimulated polymorphonuclear leukocytes. Inhibition could be blocked by catalase plus or minus superoxide dismutase. Treatment of macrophages at 4 degrees C with H2O2 had no effect on ligand binding, whereas treatment with H2O2 at 37 degrees C reduced binding to 15% of control levels and decreased the number of surface receptors to one-third of control cells. H2O2 treatment inhibited ligand degradation by macrophages, but did not prevent ligand movement from the surface to the interior of the cell. In addition, ligand delivery to lysosomes was blocked by oxidant treatment. These results suggest that treatment of macrophages with reagent H2O2 or H2O2-generating systems inhibits the normal ligand delivery and receptor recycling process involving the mannose receptor. Potential mechanisms might include receptor oxidation, alterations in ATP levels, or membrane lipid peroxidation." @default.
- W1566267517 created "2016-06-24" @default.
- W1566267517 creator A5009321920 @default.
- W1566267517 creator A5042933114 @default.
- W1566267517 creator A5057332286 @default.
- W1566267517 date "1988-01-01" @default.
- W1566267517 modified "2023-09-29" @default.
- W1566267517 title "Oxidant-mediated inhibition of ligand uptake by the macrophage mannose receptor." @default.
- W1566267517 cites W1423560049 @default.
- W1566267517 cites W1453079484 @default.
- W1566267517 cites W1482559745 @default.
- W1566267517 cites W1516050685 @default.
- W1566267517 cites W1540076991 @default.
- W1566267517 cites W1555196812 @default.
- W1566267517 cites W1585969322 @default.
- W1566267517 cites W1595656597 @default.
- W1566267517 cites W1597702906 @default.
- W1566267517 cites W1601623162 @default.
- W1566267517 cites W1743281953 @default.
- W1566267517 cites W2024182441 @default.
- W1566267517 cites W2040283218 @default.
- W1566267517 cites W2042898710 @default.
- W1566267517 cites W2083586816 @default.
- W1566267517 cites W2087112811 @default.
- W1566267517 cites W2088084755 @default.
- W1566267517 cites W2103351521 @default.
- W1566267517 cites W2118042752 @default.
- W1566267517 cites W2120197534 @default.
- W1566267517 cites W2121592233 @default.
- W1566267517 cites W2149817638 @default.
- W1566267517 cites W2166301893 @default.
- W1566267517 cites W2172982769 @default.
- W1566267517 cites W2214973860 @default.
- W1566267517 cites W2345840229 @default.
- W1566267517 doi "https://doi.org/10.1016/s0021-9258(19)57292-1" @default.
- W1566267517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3335543" @default.
- W1566267517 hasPublicationYear "1988" @default.
- W1566267517 type Work @default.
- W1566267517 sameAs 1566267517 @default.
- W1566267517 citedByCount "36" @default.
- W1566267517 countsByYear W15662675172012 @default.
- W1566267517 countsByYear W15662675172013 @default.
- W1566267517 crossrefType "journal-article" @default.
- W1566267517 hasAuthorship W1566267517A5009321920 @default.
- W1566267517 hasAuthorship W1566267517A5042933114 @default.
- W1566267517 hasAuthorship W1566267517A5057332286 @default.
- W1566267517 hasBestOaLocation W15662675171 @default.
- W1566267517 hasConcept C116569031 @default.
- W1566267517 hasConcept C170493617 @default.
- W1566267517 hasConcept C185592680 @default.
- W1566267517 hasConcept C202751555 @default.
- W1566267517 hasConcept C2775887612 @default.
- W1566267517 hasConcept C2776205754 @default.
- W1566267517 hasConcept C2779244956 @default.
- W1566267517 hasConcept C55493867 @default.
- W1566267517 hasConcept C86803240 @default.
- W1566267517 hasConcept C95444343 @default.
- W1566267517 hasConceptScore W1566267517C116569031 @default.
- W1566267517 hasConceptScore W1566267517C170493617 @default.
- W1566267517 hasConceptScore W1566267517C185592680 @default.
- W1566267517 hasConceptScore W1566267517C202751555 @default.
- W1566267517 hasConceptScore W1566267517C2775887612 @default.
- W1566267517 hasConceptScore W1566267517C2776205754 @default.
- W1566267517 hasConceptScore W1566267517C2779244956 @default.
- W1566267517 hasConceptScore W1566267517C55493867 @default.
- W1566267517 hasConceptScore W1566267517C86803240 @default.
- W1566267517 hasConceptScore W1566267517C95444343 @default.
- W1566267517 hasIssue "3" @default.
- W1566267517 hasLocation W15662675171 @default.
- W1566267517 hasOpenAccess W1566267517 @default.
- W1566267517 hasPrimaryLocation W15662675171 @default.
- W1566267517 hasRelatedWork W113914089 @default.
- W1566267517 hasRelatedWork W1534776731 @default.
- W1566267517 hasRelatedWork W1827773344 @default.
- W1566267517 hasRelatedWork W1980427216 @default.
- W1566267517 hasRelatedWork W2053061893 @default.
- W1566267517 hasRelatedWork W2065548145 @default.
- W1566267517 hasRelatedWork W2077344672 @default.
- W1566267517 hasRelatedWork W2338171589 @default.
- W1566267517 hasRelatedWork W3029773825 @default.
- W1566267517 hasRelatedWork W3111904808 @default.
- W1566267517 hasVolume "263" @default.
- W1566267517 isParatext "false" @default.
- W1566267517 isRetracted "false" @default.
- W1566267517 magId "1566267517" @default.
- W1566267517 workType "article" @default.