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• W1566276710 startingPage "29" @default.
• W1566276710 abstract "Feedback control systems are fundamental for physiological mechanisms. Disruption of feedback control almost inevitably leads to a pathological state. The consequence of a failure in negative feedback is exemplified by the adrenogenital syndrome. Failure in positive feedback is exemplified by disruption of the estrogen positive feedback on the hypothalamic pituitary system, which results in failure of the ovulatory surge of luteinizing hormone (LH) and consequent female infertility. Crucial for homeostasis, negative feedback control mechanisms are comprised of a system in which the output moderates the strength of the controller to a predetermined set-point level. The set-point-stimulator complex contains a comparator (error detector) that compares the strength of the feedback signal with a preset level. An increase in the strength of the feedback signal above the preset level reduces the output of the stimulator; a decrease in strength of the feedback signal below the preset level results in an increase in output of the stimulator—that is, the comparator determines the actual and the preset level of the feedback signal and corrects the error. Negative feedback control operates widely throughout the body at the molecular (e.g., end-product inhibition of enzyme activity), cellular, and whole systems/body level. Positive feedback, whereby the output of a system increases the output of the stimulator (gain in the system), is far less common than negative feedback, possibly because taken to its logical conclusion a positive feedback system will eventually self-destruct." @default.
• W1566276710 created "2016-06-24" @default.
• W1566276710 creator A5076966259 @default.
• W1566276710 date "1997-01-01" @default.
• W1566276710 modified "2023-09-27" @default.
• W1566276710 title "Mechanisms of Negative and Positive Feedback of Steroids in the Hypothalamic–Pituitary System" @default.
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