Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566286579> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1566286579 endingPage "239" @default.
- W1566286579 startingPage "231" @default.
- W1566286579 abstract "Most gene expression systems currently under development for gene therapy applications, whether viral or nonviral, produce therapeutic proteins constitutively and provide no means to regulate the dose of the therapeutic gene. Thus, there is a recognized need for gene expression systems that can be tightly controlled. Recently, a number of gene expression systems have been developed that can be regulated by the administration of specific small molecule drugs. These systems require the expression of genetically engineered regulatory proteins that function as molecular switches or gene switches. This chapter describes a number of novel gene switches and discusses their potential use for in vivo human gene therapy. As understanding of gene transcription has increased, it has become possible to design gene expression systems that regulate the expression of exogenously-administered target genes by controlling the interaction of transcription factors (TFs), with specific response elements in the target gene's promoter or enhancer. Most approaches use similar strategies and involve the genetic engineering of chimeric transcription factors that contain a domain capable of binding to a specific response element in the promoter/enhancer of the target gene (DNA-binding domain), a domain capable of binding a specific ligand or small molecule drug to regulate the DNA binding activity (ligand-binding domain), and a domain capable of stimulating or repressing the transcriptional process (transactivation or transrepression domain). These chimeric transcription factors function as gene switches because they are capable of switching the transcription of a target gene on or off in response to administration of the ligand or small molecule drug. Other successful approaches to the regulated target gene expression are based on the generation of novel, chimeric transcription factors, derived from either bacterial repressor proteins or mammalian transcription factors. The chapter includes discussion of these two types of gene switches." @default.
- W1566286579 created "2016-06-24" @default.
- W1566286579 creator A5071134411 @default.
- W1566286579 creator A5076466340 @default.
- W1566286579 date "1997-01-01" @default.
- W1566286579 modified "2023-09-23" @default.
- W1566286579 title "Chapter 23. Novel Gene Switches for the Regulation of Gene Expression" @default.
- W1566286579 cites W1926475069 @default.
- W1566286579 cites W1965442713 @default.
- W1566286579 cites W1965895243 @default.
- W1566286579 cites W1967013096 @default.
- W1566286579 cites W1970586355 @default.
- W1566286579 cites W1976619281 @default.
- W1566286579 cites W1981939829 @default.
- W1566286579 cites W1982782319 @default.
- W1566286579 cites W1988607142 @default.
- W1566286579 cites W1993580305 @default.
- W1566286579 cites W2000517171 @default.
- W1566286579 cites W2000748804 @default.
- W1566286579 cites W2005275397 @default.
- W1566286579 cites W2007048730 @default.
- W1566286579 cites W2007095985 @default.
- W1566286579 cites W2016955606 @default.
- W1566286579 cites W2021824698 @default.
- W1566286579 cites W2030326532 @default.
- W1566286579 cites W2030537197 @default.
- W1566286579 cites W2033433686 @default.
- W1566286579 cites W2053611710 @default.
- W1566286579 cites W2058303636 @default.
- W1566286579 cites W2065519715 @default.
- W1566286579 cites W2072291835 @default.
- W1566286579 cites W2076432794 @default.
- W1566286579 cites W2080842144 @default.
- W1566286579 cites W2088948596 @default.
- W1566286579 cites W2090383600 @default.
- W1566286579 cites W2090429649 @default.
- W1566286579 cites W2121625670 @default.
- W1566286579 cites W2155769207 @default.
- W1566286579 doi "https://doi.org/10.1016/s0065-7743(08)61481-5" @default.
- W1566286579 hasPublicationYear "1997" @default.
- W1566286579 type Work @default.
- W1566286579 sameAs 1566286579 @default.
- W1566286579 citedByCount "4" @default.
- W1566286579 crossrefType "book-chapter" @default.
- W1566286579 hasAuthorship W1566286579A5071134411 @default.
- W1566286579 hasAuthorship W1566286579A5076466340 @default.
- W1566286579 hasConcept C104317684 @default.
- W1566286579 hasConcept C150194340 @default.
- W1566286579 hasConcept C54355233 @default.
- W1566286579 hasConcept C70721500 @default.
- W1566286579 hasConcept C86803240 @default.
- W1566286579 hasConcept C95444343 @default.
- W1566286579 hasConceptScore W1566286579C104317684 @default.
- W1566286579 hasConceptScore W1566286579C150194340 @default.
- W1566286579 hasConceptScore W1566286579C54355233 @default.
- W1566286579 hasConceptScore W1566286579C70721500 @default.
- W1566286579 hasConceptScore W1566286579C86803240 @default.
- W1566286579 hasConceptScore W1566286579C95444343 @default.
- W1566286579 hasLocation W15662865791 @default.
- W1566286579 hasOpenAccess W1566286579 @default.
- W1566286579 hasPrimaryLocation W15662865791 @default.
- W1566286579 hasRelatedWork W1991523530 @default.
- W1566286579 hasRelatedWork W2002128513 @default.
- W1566286579 hasRelatedWork W2009966535 @default.
- W1566286579 hasRelatedWork W2020824267 @default.
- W1566286579 hasRelatedWork W2031436818 @default.
- W1566286579 hasRelatedWork W2075354549 @default.
- W1566286579 hasRelatedWork W2119103177 @default.
- W1566286579 hasRelatedWork W2171277769 @default.
- W1566286579 hasRelatedWork W2179689986 @default.
- W1566286579 hasRelatedWork W2092874662 @default.
- W1566286579 isParatext "false" @default.
- W1566286579 isRetracted "false" @default.
- W1566286579 magId "1566286579" @default.
- W1566286579 workType "book-chapter" @default.