FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566288052> ?p ?o ?g. }

• W1566288052 endingPage "208" @default.
• W1566288052 startingPage "200" @default.
• W1566288052 abstract "J. Neurochem. (2010) 115, 200–208. Abstract The choroid plexuses (CP) are responsible for transport of micronutrients into brain and clearance of toxic compounds, in addition to its barrier function and production of CSF. Multidrug resistance-associated protein (Mrp) 4 is one transport protein highly expressed in CP tissue and is characterized as a versatile pump for toxicants and signalling molecules. Aim of the study was to determine transport characteristics of a fluorescent cAMP analog in rat CP and to define whether fluo-cAMP can be used for analyses of function, substrate/inhibitor specificity and regulation of Mrp4. Confocal imaging was used to analyze transport mechanisms in absence and presence of various modulators of organic anion transport in freshly isolated and functionally intact CP. Fluo-cAMP transport was saturable, selective, concentrative and metabolism-dependent, following an active two-step mechanism composed of apical uptake into epithelial cells and basolateral efflux. Uptake included a Na+-dependent and a Na+-independent component and was inhibited by estrone sulfate, taurocholate and sildenafil indicating involvement of organic anion transporting polypeptide Oatp1a5. Efflux was composed of an indirect Na+-dependent component and a component inhibitable by, for example, the MRP4 substrates/inhibitors, sulindac sulfide and 4-(2-aminoethyl) benzenesulfonyl fluoride. Therefore, fluo-cAMP can be used as fluorescent model compound for studying involvement of Mrp4 in signalling pathways and neuroprotection in CP." @default.
• W1566288052 created "2016-06-24" @default.
• W1566288052 creator A5023496318 @default.
• W1566288052 creator A5024106348 @default.
• W1566288052 creator A5047818086 @default.
• W1566288052 creator A5081513873 @default.
• W1566288052 date "2010-08-19" @default.
• W1566288052 modified "2023-09-26" @default.
• W1566288052 title "Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus" @default.
• W1566288052 cites W1966431705 @default.
• W1566288052 cites W1980679007 @default.
• W1566288052 cites W1984613701 @default.
• W1566288052 cites W2020849388 @default.
• W1566288052 cites W2032614864 @default.
• W1566288052 cites W2033893252 @default.
• W1566288052 cites W2043537507 @default.
• W1566288052 cites W2050218316 @default.
• W1566288052 cites W2072587281 @default.
• W1566288052 cites W2074034640 @default.
• W1566288052 cites W2076536269 @default.
• W1566288052 cites W2081750550 @default.
• W1566288052 cites W2090832446 @default.
• W1566288052 cites W2091266206 @default.
• W1566288052 cites W2094952370 @default.
• W1566288052 cites W2099129363 @default.
• W1566288052 cites W2100808729 @default.
• W1566288052 cites W2102991688 @default.
• W1566288052 cites W2105059388 @default.
• W1566288052 cites W2106576905 @default.
• W1566288052 cites W2106762675 @default.
• W1566288052 cites W2107703226 @default.
• W1566288052 cites W2107913942 @default.
• W1566288052 cites W2111567736 @default.
• W1566288052 cites W2121675373 @default.
• W1566288052 cites W2122269058 @default.
• W1566288052 cites W2125542198 @default.
• W1566288052 cites W2126799336 @default.
• W1566288052 cites W2137972059 @default.
• W1566288052 cites W2143189887 @default.
• W1566288052 cites W2143785451 @default.
• W1566288052 cites W2151049164 @default.
• W1566288052 cites W2152702915 @default.
• W1566288052 cites W2152732346 @default.
• W1566288052 cites W2156094398 @default.
• W1566288052 cites W2156871638 @default.
• W1566288052 cites W2160034626 @default.
• W1566288052 cites W2161534034 @default.
• W1566288052 cites W2162742227 @default.
• W1566288052 cites W2165860016 @default.
• W1566288052 cites W2171073522 @default.
• W1566288052 doi "https://doi.org/10.1111/j.1471-4159.2010.06915.x" @default.
• W1566288052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20649844" @default.
• W1566288052 hasPublicationYear "2010" @default.
• W1566288052 type Work @default.
• W1566288052 sameAs 1566288052 @default.
• W1566288052 citedByCount "15" @default.
• W1566288052 countsByYear W15662880522012 @default.
• W1566288052 countsByYear W15662880522014 @default.
• W1566288052 countsByYear W15662880522015 @default.
• W1566288052 countsByYear W15662880522017 @default.
• W1566288052 countsByYear W15662880522019 @default.
• W1566288052 countsByYear W15662880522021 @default.
• W1566288052 countsByYear W15662880522022 @default.
• W1566288052 crossrefType "journal-article" @default.
• W1566288052 hasAuthorship W1566288052A5023496318 @default.
• W1566288052 hasAuthorship W1566288052A5024106348 @default.
• W1566288052 hasAuthorship W1566288052A5047818086 @default.
• W1566288052 hasAuthorship W1566288052A5081513873 @default.
• W1566288052 hasConcept C104317684 @default.
• W1566288052 hasConcept C115335371 @default.
• W1566288052 hasConcept C123584848 @default.
• W1566288052 hasConcept C12554922 @default.
• W1566288052 hasConcept C134018914 @default.
• W1566288052 hasConcept C149011108 @default.
• W1566288052 hasConcept C185592680 @default.
• W1566288052 hasConcept C189613389 @default.
• W1566288052 hasConcept C200082930 @default.
• W1566288052 hasConcept C2776538271 @default.
• W1566288052 hasConcept C2776678969 @default.
• W1566288052 hasConcept C2776872141 @default.
• W1566288052 hasConcept C2778656385 @default.
• W1566288052 hasConcept C2779149875 @default.
• W1566288052 hasConcept C2910769707 @default.
• W1566288052 hasConcept C36201501 @default.
• W1566288052 hasConcept C39587587 @default.
• W1566288052 hasConcept C41625074 @default.
• W1566288052 hasConcept C44312359 @default.
• W1566288052 hasConcept C512196 @default.
• W1566288052 hasConcept C529278444 @default.
• W1566288052 hasConcept C55493867 @default.
• W1566288052 hasConcept C57581600 @default.
• W1566288052 hasConcept C71315377 @default.
• W1566288052 hasConcept C86803240 @default.
• W1566288052 hasConcept C95444343 @default.
• W1566288052 hasConceptScore W1566288052C104317684 @default.
• W1566288052 hasConceptScore W1566288052C115335371 @default.
• W1566288052 hasConceptScore W1566288052C123584848 @default.
• W1566288052 hasConceptScore W1566288052C12554922 @default.

• next