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- W156629225 abstract "Sterol regulatory element binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to the nuclear envelope and endoplasmic reticulum membranes. In cells with low levels of sterols, SREBPs are cleaved to a water soluble N-terminal domain which is translocated to the nucleus. These activated SREBPs then bind to specific sterol regulatory element DNA sequences which upregulate the synthesis of enzymes involved in sterol biosynthesis. Sterols in turn inhibit the cleavage of SREBPs and therefore synthesis of additional sterols is reduced through a negative feed back loop. (The Journal of American Science. 2008;4(2):88-94). (ISSN 1545-1003)." @default.
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- W156629225 date "2008-01-01" @default.
- W156629225 modified "2023-09-27" @default.
- W156629225 title "Sterol Regulatory Element Binding Proteins (SREBPs)" @default.
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