FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566302744> ?p ?o ?g. }

• W1566302744 endingPage "1183" @default.
• W1566302744 startingPage "1176" @default.
• W1566302744 abstract "Background Glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 are multifunctional enzymes involved in the detoxification of a wide range of reactive oxygen species produced during melanin synthesis and oxidative stress processes. Objectives Single nucleotide polymorphisms (SNPs) in GSTP1 and copy number variants in GSTM1 and GSTT1 may be candidate low-penetrance variants with a role in susceptibility to malignant melanoma (MM). Methods In this case–control study, 562 Spanish patients with sporadic MM and 338 cancer-free control subjects were included, and the role of polymorphisms in these GST genes was investigated. Genotypes were established by quantitative real-time polymerase chain reaction for GSTM1 and GSTT1 while TaqMan probes were used to genotype GSTP1 SNPs. Results The GSTP1 polymorphism rs1695, which encodes the amino acid change p.Ile105Val, was individually associated with MM [odds ratio (OR): 1·32, 95% confidence interval (CI): 1·06–1·63]. Furthermore, individuals carrying one or two MC1R nonsynonymous changes and GSTP1 rs1695 rare allele had an increased risk of developing MM (OR: 3·34, 95% CI: 1·42–8·09 and OR: 20·42, 95% CI: 2·80–417·42, respectively). Conclusions This is the first time that the GSTP1 rs1695 polymorphism is reported to be associated with MM. In addition, this study is one of the largest GST polymorphism studies undertaken in the Spanish population and the first time that copy number variants have been scrutinized in relation to MM." @default.
• W1566302744 created "2016-06-24" @default.
• W1566302744 creator A5016706433 @default.
• W1566302744 creator A5026179323 @default.
• W1566302744 creator A5034653708 @default.
• W1566302744 creator A5076020590 @default.
• W1566302744 creator A5076649912 @default.
• W1566302744 creator A5081663145 @default.
• W1566302744 date "2012-04-04" @default.
• W1566302744 modified "2023-10-16" @default.
• W1566302744 title "Role of glutathione S-transferases in melanoma susceptibility: association with GSTP1 rs1695 polymorphism" @default.
• W1566302744 cites W1488999870 @default.
• W1566302744 cites W1600775215 @default.
• W1566302744 cites W1969809385 @default.
• W1566302744 cites W1971336406 @default.
• W1566302744 cites W1981605211 @default.
• W1566302744 cites W1995584424 @default.
• W1566302744 cites W2005039507 @default.
• W1566302744 cites W2008342966 @default.
• W1566302744 cites W2013035104 @default.
• W1566302744 cites W2013485244 @default.
• W1566302744 cites W2017750556 @default.
• W1566302744 cites W2026418668 @default.
• W1566302744 cites W2030600422 @default.
• W1566302744 cites W2034183785 @default.
• W1566302744 cites W2041554462 @default.
• W1566302744 cites W2051112657 @default.
• W1566302744 cites W2054955878 @default.
• W1566302744 cites W2055523163 @default.
• W1566302744 cites W2057617647 @default.
• W1566302744 cites W2057811117 @default.
• W1566302744 cites W2075825477 @default.
• W1566302744 cites W2078531129 @default.
• W1566302744 cites W2081224298 @default.
• W1566302744 cites W2092421631 @default.
• W1566302744 cites W2093747135 @default.
• W1566302744 cites W2094776252 @default.
• W1566302744 cites W2105712032 @default.
• W1566302744 cites W2123300021 @default.
• W1566302744 cites W2127998528 @default.
• W1566302744 cites W2131786855 @default.
• W1566302744 cites W2133821784 @default.
• W1566302744 cites W2167048743 @default.
• W1566302744 cites W2169323099 @default.
• W1566302744 cites W41835213 @default.
• W1566302744 cites W4300575633 @default.
• W1566302744 doi "https://doi.org/10.1111/j.1365-2133.2012.10831.x" @default.
• W1566302744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22251241" @default.
• W1566302744 hasPublicationYear "2012" @default.
• W1566302744 type Work @default.
• W1566302744 sameAs 1566302744 @default.
• W1566302744 citedByCount "39" @default.
• W1566302744 countsByYear W15663027442012 @default.
• W1566302744 countsByYear W15663027442013 @default.
• W1566302744 countsByYear W15663027442014 @default.
• W1566302744 countsByYear W15663027442015 @default.
• W1566302744 countsByYear W15663027442016 @default.
• W1566302744 countsByYear W15663027442017 @default.
• W1566302744 countsByYear W15663027442019 @default.
• W1566302744 countsByYear W15663027442020 @default.
• W1566302744 countsByYear W15663027442021 @default.
• W1566302744 countsByYear W15663027442022 @default.
• W1566302744 countsByYear W15663027442023 @default.
• W1566302744 crossrefType "journal-article" @default.
• W1566302744 hasAuthorship W1566302744A5016706433 @default.
• W1566302744 hasAuthorship W1566302744A5026179323 @default.
• W1566302744 hasAuthorship W1566302744A5034653708 @default.
• W1566302744 hasAuthorship W1566302744A5076020590 @default.
• W1566302744 hasAuthorship W1566302744A5076649912 @default.
• W1566302744 hasAuthorship W1566302744A5081663145 @default.
• W1566302744 hasConcept C104317684 @default.
• W1566302744 hasConcept C126322002 @default.
• W1566302744 hasConcept C127716648 @default.
• W1566302744 hasConcept C135763542 @default.
• W1566302744 hasConcept C153209595 @default.
• W1566302744 hasConcept C156957248 @default.
• W1566302744 hasConcept C180754005 @default.
• W1566302744 hasConcept C181199279 @default.
• W1566302744 hasConcept C200544954 @default.
• W1566302744 hasConcept C2776907368 @default.
• W1566302744 hasConcept C2780122483 @default.
• W1566302744 hasConcept C538909803 @default.
• W1566302744 hasConcept C54355233 @default.
• W1566302744 hasConcept C55493867 @default.
• W1566302744 hasConcept C71924100 @default.
• W1566302744 hasConcept C86803240 @default.
• W1566302744 hasConceptScore W1566302744C104317684 @default.
• W1566302744 hasConceptScore W1566302744C126322002 @default.
• W1566302744 hasConceptScore W1566302744C127716648 @default.
• W1566302744 hasConceptScore W1566302744C135763542 @default.
• W1566302744 hasConceptScore W1566302744C153209595 @default.
• W1566302744 hasConceptScore W1566302744C156957248 @default.
• W1566302744 hasConceptScore W1566302744C180754005 @default.
• W1566302744 hasConceptScore W1566302744C181199279 @default.
• W1566302744 hasConceptScore W1566302744C200544954 @default.
• W1566302744 hasConceptScore W1566302744C2776907368 @default.
• W1566302744 hasConceptScore W1566302744C2780122483 @default.
• W1566302744 hasConceptScore W1566302744C538909803 @default.

• next