FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1566309247> ?p ?o ?g. }

• W1566309247 endingPage "163" @default.
• W1566309247 startingPage "156" @default.
• W1566309247 abstract "The secreted phosphoprotein osteopontin (OPN) is strongly associated with the process of neoplastic transformation, based both on its pattern of expression in vivo and in vitro and on functional analyses. We have used 3T3 cells derived from wildtype and OPN-deficient mice and transformed by transfection with oncogenic ras to assess the role of OPN in transformation in vitro and in tumorigenesis in vivo. There was no effect of an absence of OPN on the ability of the cells to undergo immortalization or to form morphologically transformed foci following ras transfection. Wildtype and OPN-deficient cell lines were established from such foci, and lines with similar ras mRNA levels selected for further analysis. Ras-transformed cell lines from both wildtype and OPN-deficient mice could form colonies in soft agar indicating that this process can occur in the absence of OPN. However, the ability of the OPN-deficient cell lines to form colonies was reduced as compared to wildtype cell lines. Tumorigenesis in syngeneic and nude mice was assessed for a subset of cell lines that formed colonies efficiently in soft agar. Cell lines unable to make OPN formed tumors in these mice much more slowly than wildtype cells, despite similar growth of the cells on plastic and in soft agar. Taken together, these results indicate that maximal transformation by ras requires OPN expression, and implicate increased OPN expression as an important effector of the transforming activity of the ras oncogene." @default.
• W1566309247 created "2016-06-24" @default.
• W1566309247 creator A5027560531 @default.
• W1566309247 creator A5034603708 @default.
• W1566309247 creator A5038252085 @default.
• W1566309247 date "2000-07-01" @default.
• W1566309247 modified "2023-10-10" @default.
• W1566309247 title "Osteopontin is required for full expression of the transformed phenotype by the ras oncogene" @default.
• W1566309247 cites W12947604 @default.
• W1566309247 cites W1534278651 @default.
• W1566309247 cites W1559835035 @default.
• W1566309247 cites W1562216281 @default.
• W1566309247 cites W1569476889 @default.
• W1566309247 cites W1605025243 @default.
• W1566309247 cites W1606122132 @default.
• W1566309247 cites W1606485575 @default.
• W1566309247 cites W1740440689 @default.
• W1566309247 cites W1839610592 @default.
• W1566309247 cites W1843320504 @default.
• W1566309247 cites W1962330182 @default.
• W1566309247 cites W1973743039 @default.
• W1566309247 cites W1975675679 @default.
• W1566309247 cites W1980855212 @default.
• W1566309247 cites W1981393628 @default.
• W1566309247 cites W1981944321 @default.
• W1566309247 cites W1988087441 @default.
• W1566309247 cites W1988869074 @default.
• W1566309247 cites W1989780564 @default.
• W1566309247 cites W1990105301 @default.
• W1566309247 cites W1991048336 @default.
• W1566309247 cites W1991953529 @default.
• W1566309247 cites W1992627352 @default.
• W1566309247 cites W1994724799 @default.
• W1566309247 cites W2001753204 @default.
• W1566309247 cites W2003051017 @default.
• W1566309247 cites W2003558980 @default.
• W1566309247 cites W2008675789 @default.
• W1566309247 cites W2010690155 @default.
• W1566309247 cites W2017315992 @default.
• W1566309247 cites W2023934008 @default.
• W1566309247 cites W2029231027 @default.
• W1566309247 cites W2029773366 @default.
• W1566309247 cites W2034842897 @default.
• W1566309247 cites W2036145275 @default.
• W1566309247 cites W2039074795 @default.
• W1566309247 cites W2039221787 @default.
• W1566309247 cites W2046086515 @default.
• W1566309247 cites W2049031103 @default.
• W1566309247 cites W2054426818 @default.
• W1566309247 cites W2057929092 @default.
• W1566309247 cites W2063719484 @default.
• W1566309247 cites W2073364617 @default.
• W1566309247 cites W2077569218 @default.
• W1566309247 cites W2090429649 @default.
• W1566309247 cites W2096846100 @default.
• W1566309247 cites W2109868881 @default.
• W1566309247 cites W2112509531 @default.
• W1566309247 cites W2134771161 @default.
• W1566309247 cites W2147830182 @default.
• W1566309247 cites W2157476088 @default.
• W1566309247 cites W2161630702 @default.
• W1566309247 cites W2166179228 @default.
• W1566309247 cites W2346692519 @default.
• W1566309247 cites W2404089531 @default.
• W1566309247 cites W2405086644 @default.
• W1566309247 cites W2411587487 @default.
• W1566309247 cites W2413031356 @default.
• W1566309247 cites W2415294652 @default.
• W1566309247 cites W2428561305 @default.
• W1566309247 doi "https://doi.org/10.1054/bjoc.2000.1200" @default.
• W1566309247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2363489" @default.
• W1566309247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10901364" @default.
• W1566309247 hasPublicationYear "2000" @default.
• W1566309247 type Work @default.
• W1566309247 sameAs 1566309247 @default.
• W1566309247 citedByCount "90" @default.
• W1566309247 countsByYear W15663092472012 @default.
• W1566309247 countsByYear W15663092472013 @default.
• W1566309247 countsByYear W15663092472014 @default.
• W1566309247 countsByYear W15663092472015 @default.
• W1566309247 countsByYear W15663092472016 @default.
• W1566309247 countsByYear W15663092472017 @default.
• W1566309247 countsByYear W15663092472018 @default.
• W1566309247 countsByYear W15663092472019 @default.
• W1566309247 countsByYear W15663092472020 @default.
• W1566309247 countsByYear W15663092472021 @default.
• W1566309247 crossrefType "journal-article" @default.
• W1566309247 hasAuthorship W1566309247A5027560531 @default.
• W1566309247 hasAuthorship W1566309247A5034603708 @default.
• W1566309247 hasAuthorship W1566309247A5038252085 @default.
• W1566309247 hasBestOaLocation W15663092471 @default.
• W1566309247 hasConcept C104317684 @default.
• W1566309247 hasConcept C121608353 @default.
• W1566309247 hasConcept C127716648 @default.
• W1566309247 hasConcept C143065580 @default.
• W1566309247 hasConcept C1491633281 @default.
• W1566309247 hasConcept C153911025 @default.
• W1566309247 hasConcept C203014093 @default.

• next